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Resolving sorting mechanisms into exosomes
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Journal Article
Resolving sorting mechanisms into exosomes
2015
Overview
The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge. In a paper recently published in Cell Research, Roucourt et al. report that trimming of heparan sulfate side chains of syndecans by cndosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.
Publisher
Nature Publishing Group UK,Nature Publishing Group
