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Efficacy of Mucoadhesive Hydrogel Microparticles of Whey Protein and Alginate for Oral Insulin Delivery

by Subirade, Muriel , Conception, Ingénierie et Développement de l'Aliment et du Médicament (CIDAM) ; Université d'Auvergne - Clermont-Ferrand I (UdA) , Université Clermont Auvergne (UCA) , Centre National de la Recherche Scientifique (CNRS) , Unité de Microbiologie (MIC) ; Institut National de la Recherche Agronomique (INRA) , Jarrige, Jean-François , Centre de recherches archéologiques indus - baluchistan - asie centrale et orientale (CRAIBACO) ; MUSEES DE FRANCE-Centre National de la Recherche Scientifique (CNRS) , Garrait, Ghislain , Université Laval [Québec] (ULaval) , Beyssac, Eric , Cardot, Jean-Michel , Déat-Lainé, Emmanuelle , Hoffart, Valérie , Mission Archéologique de l'Indus (MAI) ; Centre de recherches archéologiques indus - baluchistan - asie centrale et orientale (CRAIBACO) ; MUSEES DE FRANCE-Centre National de la Recherche Scientifique (CNRS)-MUSEES DE FRANCE-Centre National de la Recherche Scientifique (CNRS)-Ministère de l'Europe et des Affaires étrangères (MEAE) , Institute of Nutrition and Functional Foods ; U

in Administration, Oral / Alginates - chemistry / Alginates - metabolism / Animals / Biochemistry / Biological and medical sciences / Biomedical and Life Sciences / Biomedical Engineering and Bioengineering / Biomedicine / Drug Carriers - chemistry / Drug Carriers - metabolism / Drug delivery systems / Duodenum - metabolism / Duodenum - ultrastructure / Galenic pharmacology / General pharmacology / Glucuronic Acid - chemistry / Glucuronic Acid - metabolism / Hexuronic Acids - chemistry / Hexuronic Acids - metabolism / Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry / Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism / Hypoglycemic Agents - administration & dosage / Hypoglycemic Agents - metabolism / Hypoglycemic Agents - pharmacokinetics / Hypoglycemic Agents - pharmacology / Insulin / Insulin - administration & dosage / Insulin - metabolism / Insulin - pharmacokinetics / Insulin - pharmacology / Life Sciences / Male / Medical Law / Medical sciences / Microspheres / Milk Proteins - chemistry / Milk Proteins - metabolism / Pharmaceutical sciences / Pharmaceutical technology. Pharmaceutical industry / Pharmacology / Pharmacology. Drug treatments / Pharmacology/Toxicology / Pharmacy / Proteins / Rabbits / Rats / Rats, Wistar / Research Paper / Tissue Adhesives - chemistry / Tissue Adhesives - metabolism / Whey Proteins

2013

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Efficacy of Mucoadhesive Hydrogel Microparticles of Whey Protein and Alginate for Oral Insulin Delivery

2013

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Efficacy of Mucoadhesive Hydrogel Microparticles of Whey Protein and Alginate for Oral Insulin Delivery

2013

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Journal Article

Efficacy of Mucoadhesive Hydrogel Microparticles of Whey Protein and Alginate for Oral Insulin Delivery

Subirade, Muriel,

Conception, Ingénierie et Développement de l'Aliment et du Médicament (CIDAM) ; Université d'Auvergne - Clermont-Ferrand I (UdA),

Université Clermont Auvergne (UCA),

Centre National de la Recherche Scientifique (CNRS),

Unité de Microbiologie (MIC) ; Institut National de la Recherche Agronomique (INRA),

Jarrige, Jean-François,

Centre de recherches archéologiques indus - baluchistan - asie centrale et orientale (CRAIBACO) ; MUSEES DE FRANCE-Centre National de la Recherche Scientifique (CNRS),

Garrait, Ghislain,

Université Laval [Québec] (ULaval),

Beyssac, Eric,

Cardot, Jean-Michel,

Déat-Lainé, Emmanuelle,

Hoffart, Valérie,

Mission Archéologique de l'Indus (MAI) ; Centre de recherches archéologiques indus - baluchistan - asie centrale et orientale (CRAIBACO) ; MUSEES DE FRANCE-Centre National de la Recherche Scientifique (CNRS)-MUSEES DE FRANCE-Centre National de la Recherche Scientifique (CNRS)-Ministère de l'Europe et des Affaires étrangères (MEAE),

Institute of Nutrition and Functional Foods ; U

2013

Overview

Purpose To evaluate the efficacy of mucoadhesive insulinloadedwhey protein (WP) /alginate (ALG) microparticles (MP)for oral insulin administration.Methods Insulin-loaded microparticles (ins-MP) made of wheyprotein and alginate were prepared by a cold gelation techniqueand an adsorption method, without adjunction of organic solventin order to develop a biocompatible vehicle for oraladministration of insulin. In vitro characterization, evaluations ofins-MP in excised intestinal tissues and hypoglycaemic effectsafter intestinal administration in healthy rats were performedResults The release properties and swelling behaviors, investigatedin different pH buffers, demonstrated a release based ondiffusion mechanism following matrix swelling. Mucoadhesionstudies in rabbits and insulin transport experiments with excisedintestinal rat tissues revealed that encapsulation in microparticleswith mucoadhesive properties promotes insulin absorption acrossduodenal membranes and bioactivity protection. In vivo experimentsreinforced the interest of encapsulation in whey protein/alginate combination. Confocal microscopic observations associatedwith blood glucose levels bring to light duodenal absorptionof insulin biologically active following in vivo administration.Conclusions Insulin-loaded WP/ALG MP with high quantities ofdrug entrapped, in vitromatrix swelling and protective effect as wellas excellent mucohadesive properties was developped. Improvementof intestinal delivery of insulin and increased in bioavailabilitywere recorded.

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Publisher

CCSD,American Association of Pharmaceutical Scientists,Springer US,Springer,Springer Nature B.V

Subject

Administration, Oral

/ Alginates - chemistry

/ Alginates - metabolism

/ Animals

/ Biochemistry

/ Biological and medical sciences

/ Biomedical and Life Sciences