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N,N’-Substituted Selenoureas as Polyfunctional Antioxidants
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N,N’-Substituted Selenoureas as Polyfunctional Antioxidants
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Journal Article
N,N’-Substituted Selenoureas as Polyfunctional Antioxidants
2016
Overview
Analysis of antioxidant activity of synthesized selenourea derivatives showed that N,N’-substituted selenoureas inhibited Fe(III)-induced LPO in rat brain homogenate. On the other hand, oxygen- and sulfur-containing analogs exhibited no antioxidant activity or even slight prooxidant activity. Intramolecular alkylation of selenium atom also led to loss of antioxidant activity. Thus, antioxidant activity of the compounds was due to the presence of a nonalkylated selenium atom in N,N’-substituted selenourea analogs.
Publisher
Springer US,Springer,Springer Nature B.V
