Asset Details
Do you wish to reserve the book?
Induction of antibacterial proteins and peptides in the coprophilous mushroom Coprinopsis cinerea in response to bacteria
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Induction of antibacterial proteins and peptides in the coprophilous mushroom Coprinopsis cinerea in response to bacteria
Do you wish to request the book?
Induction of antibacterial proteins and peptides in the coprophilous mushroom Coprinopsis cinerea in response to bacteria
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Induction of antibacterial proteins and peptides in the coprophilous mushroom Coprinopsis cinerea in response to bacteria
2019
Overview
Bacteria are the main nutritional competitors of saprophytic fungi during colonization of their ecological niches. This competition involves the mutual secretion of antimicrobials that kill or inhibit the growth of the competitor. Over the last years it has been demonstrated that fungi respond to the presence of bacteria with changes of their transcriptome, but the significance of these changes with respect to competition for nutrients is not clear as functional proof of the antibacterial activity of the induced gene products is often lacking. Here, we report the genome-wide transcriptional response of the coprophilous mushroom
Coprinopsis cinerea
to the bacteria
Bacillus subtilis
and
Escherichia coli
. The genes induced upon co-cultivation with each bacterium were highly overlapping, suggesting that the fungus uses a similar arsenal of effectors against Gram-positive and -negative bacteria. Intriguingly, the induced genes appeare to encode predominantly secreted peptides and proteins with predicted antibacterial activities, which was validated by comparative proteomics of the
C. cinerea
secretome. Induced members of two putative antibacterial peptide and protein families in
C. cinerea
, the cysteine-stabilized αβ-defensins (Csαβ-defensins) and the GH24-type lysozymes, were purified, and their antibacterial activity was confirmed. These results provide compelling evidence that fungi are able to recognize the presence of bacteria and respond with the expression of an arsenal of secreted antibacterial peptides and proteins.
Publisher
Nature Publishing Group UK,Oxford University Press
Subject
/ 38/39
/ 38/70
/ 38/77
/ 38/91
/ 42/44
/ 82/16
/ 82/29
/ 82/47
/ 82/58
/ 82/80
/ 82/83
/ Anti-Bacterial Agents - metabolism
/ Anti-Bacterial Agents - pharmacology
/ Bacillus subtilis - physiology
/ Bacteria
/ Biomedical and Life Sciences
/ E coli
/ Ecology
/ Escherichia coli - physiology
/ Fungal Proteins - metabolism
/ Fungal Proteins - pharmacology
/ Fungi
/ Genes
/ Genomes
/ Microbial Genetics and Genomics
/ Niches
/ Peptides
/ Proteins
