Journal Article

The Impact of Decaffeinated Green Tea Extract on Fat Oxidation, Body Composition and Cardio-Metabolic Health in Overweight, Recreationally Active Individuals

Davies, Rory, Roberts, Justin D., Del Coso, Juan, Willmott, Ashley G. B., Boal, Mariette, Martin, Laurence, Gautam, Lata, Beasley, Liam, Chichger, Havovi

2021

Overview

This study investigated the effect of decaffeinated green tea extract (dGTE), with or without antioxidant nutrients, on fat oxidation, body composition and cardio-metabolic health measures in overweight individuals engaged in regular exercise. Twenty-seven participants (20 females, 7 males; body mass: 77.5 ± 10.5 kg; body mass index: 27.4 ± 3.0 kg·m2; peak oxygen uptake (V.O2peak): 30.2 ± 5.8 mL·kg−1·min−1) were randomly assigned, in a double-blinded manner, either: dGTE (400 mg·d−1 (−)-epigallocatechin−3-gallate (EGCG), n = 9); a novel dGTE+ (400 mg·d−1 EGCG, quercetin (50 mg·d−1) and α-lipoic acid (LA, 150 mg·d−1), n = 9); or placebo (PL, n = 9) for 8 weeks, whilst maintaining standardised, aerobic exercise. Fat oxidation (‘FATMAX’ and steady state exercise protocols), body composition, cardio-metabolic and blood measures (serum glucose, insulin, leptin, adiponectin, glycerol, free fatty acids, total cholesterol, high [HDL-c] and low-density lipoprotein cholesterol [LDL-c], triglycerides, liver enzymes and bilirubin) were assessed at baseline, week 4 and 8. Following 8 weeks of dGTE+, maximal fat oxidation (MFO) significantly improved from 154.4 ± 20.6 to 224.6 ± 23.2 mg·min−1 (p = 0.009), along with a 22.5% increase in the exercise intensity at which fat oxidation was deemed negligible (FATMIN; 67.6 ± 3.6% V.O2peak, p = 0.003). Steady state exercise substrate utilisation also improved for dGTE+ only, with respiratory exchange ratio reducing from 0.94 ± 0.01 at week 4, to 0.89 ± 0.01 at week 8 (p = 0.004). This corresponded with a significant increase in the contribution of fat to energy expenditure for dGTE+ from 21.0 ± 4.1% at week 4, to 34.6 ± 4.7% at week 8 (p = 0.006). LDL-c was also lower (normalised fold change of −0.09 ± 0.06) for dGTE+ by week 8 (p = 0.038). No other significant effects were found in any group. Eight weeks of dGTE+ improved MFO and substrate utilisation during exercise, and lowered LDL-c. However, body composition and cardio-metabolic markers in healthy, overweight individuals who maintained regular physical activity were largely unaffected by dGTE.

• Publisher: MDPI AG,MDPI
• Subject: adiponectin / Adiponectin - blood / Adipose Tissue - drug effects / Adult / Aerobics / Antioxidants / Antioxidants - administration & dosage / bilirubin / Bilirubin - blood / Bioavailability / blood / blood glucose / Blood Glucose - drug effects / Blood pressure / Body composition / Body Composition - drug effects / Body fat / Body Mass Index / Caffeine / Cardiometabolic Risk Factors / Catecholamines / Cholesterol - blood / decaffeination / Double-Blind Method / energy expenditure / Energy Metabolism - drug effects / Enzymes - blood / epigallocatechin gallate / Exercise / Exercise - physiology / Fatty Acids, Nonesterified - blood / Female / Gene expression / glycerol / Glycerol - blood / green tea / Humans / insulin / Insulin - blood / Intervention / Kinases / Laboratories / leptin / Leptin - blood / lipid metabolism / liver / low density lipoprotein cholesterol / Male / Metabolism / Metabolites / Middle Aged / Overweight / Overweight - physiopathology / Overweight - therapy / Oxidation / Oxidation-Reduction - drug effects / Oxygen Consumption - drug effects / peak oxygen uptake / Physical fitness / placebos / Plant Extracts - administration & dosage / Proteins / quercetin / Risk factors / Tea