Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study

by Haldar, Sumanto , Henry, Christiani Jeyakumar , Chia, Siok Ching , Lee, Sze Han , Tan, Jun Jie , Chan, Eric Chun Yong

in Acids / Adult / Area Under Curve / aromatic acids / biomarkers / Biomarkers - blood / blood plasma / Capsicum - chemistry / Chromatography, Liquid / Cinnamates - blood / cinnamic acid / Cinnamomum zeylanicum - chemistry / Coriandrum - chemistry / Cross-Over Studies / Cuminum - chemistry / Curcuma - chemistry / curry / Diet / dose response / Dose-Response Relationship, Drug / Eating / Humans / liquid chromatography / Male / males / Phenylacetates - blood / phenylacetic acid / Plant Extracts - blood / Plasma / Plasma - metabolism / Polyphenols / Polyphenols - blood / Postprandial Period / Spices - analysis / Spices - statistics & numerical data / tandem mass spectrometry / Young Adult

2018

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study

by Haldar, Sumanto , Henry, Christiani Jeyakumar , Chia, Siok Ching , Lee, Sze Han , Tan, Jun Jie , Chan, Eric Chun Yong

2018

Confirm

Do you wish to request the book?

Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study

by Haldar, Sumanto , Henry, Christiani Jeyakumar , Chia, Siok Ching , Lee, Sze Han , Tan, Jun Jie , Chan, Eric Chun Yong

2018

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study

Haldar, Sumanto,

Henry, Christiani Jeyakumar,

Chia, Siok Ching,

Lee, Sze Han,

Tan, Jun Jie,

Chan, Eric Chun Yong

2018

Overview

Spices that are rich in polyphenols are metabolized to a convergent group of phenolic/aromatic acids. We conducted a dose-exposure nutrikinetic study to investigate associations between mixed spices intake and plasma concentrations of selected, unconjugated phenolic/aromatic acids. In a randomized crossover study, 17 Chinese males consumed a curry meal containing 0 g, 6 g, and 12 g of mixed spices. Postprandial blood was drawn up to 7 h at regular intervals and plasma phenolic/aromatic acids were quantified via liquid chromatography tandem mass spectrometry (LC-MS/MS). Cinnamic acid (CNA, p < 0.0001) and phenylacetic acid (PAA, p < 0.0005) concentrations were significantly increased with mixed spices consumption, although none of the other measured phenolic/aromatic acids differ significantly between treatments. CNA displayed a high dose-exposure association (R2 > 0.8, p < 0.0001). The adjusted mean area under the plasma concentration-time curve until 7 h (AUC0–7 h) for CNA during the 3 increasing doses were 8.4 ± 3.4, 376.1 ± 104.7 and 875.7 ± 291.9 nM.h respectively. Plasma CNA concentration may be used as a biomarker of spice intake.

Share this book

Add to My Shelf

Publisher

MDPI AG,MDPI

Subject

/ Adult