Journal Article

Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study

Byrne, Claire S, Holmes, Elaine, Preston, Tom, Brignardello, Jerusa, Frost, Gary S, Tedford, Catriona, Chambers, Edward S, Wallis, Gareth A, Morrison, Douglas J, Garcia-Perez, Isabel

2019

Overview

Supplementation with inulin-propionate ester (IPE), which delivers propionate to the colon, suppresses ad libitum energy intake and stimulates the release of satiety hormones acutely in humans, and prevents weight gain. In order to determine whether IPE remains effective when incorporated into food products (FP), IPE needs to be added to a widely accepted food system. A bread roll and fruit smoothie were produced. Twenty-one healthy overweight and obese humans participated. Participants attended an acclimatisation visit and a control visit where they consumed un-supplemented food products (FP). Participants then consumed supplemented-FP, containing 10 g/d inulin or IPE for six days followed by a post-supplementation visit in a randomised crossover design. On study visits, supplemented-FP were consumed for the seventh time and ad libitum energy intake was assessed 420 min later. Blood samples were collected to assess hormones and metabolites. Resting energy expenditure (REE) was measured using indirect calorimetry. Taste and appearance ratings were similar between FP. Ad libitum energy intake was significantly different between treatments, due to a decreased intake following IPE-FP. These observations were not related to changes in blood hormones and metabolites. There was an increase in REE following IPE-FP. However, this effect was lost after correcting for changes in fat free mass. Our results suggest that IPE suppresses appetite and may alter REE following its incorporation into palatable food products.

• Publisher: MDPI AG,MDPI
• Subject: acclimation / Anti-Obesity Agents - pharmacology / Anti-Obesity Agents - therapeutic use / Appetite / Appetite - drug effects / Basal Metabolism - drug effects / blood / blood sampling / breads / calorimetry / Calorimetry, Indirect / College campuses / Colon / Cross-Over Studies / Dietary Supplements / Double-Blind Method / Energy / Energy intake / Energy Intake - drug effects / Fatty acids / Female / Food Handling / Food products / fruits / Hormones / Hormones - blood / Humans / Intervention / inulin / Inulin - pharmacology / Inulin - therapeutic use / lean body mass / Male / Metabolism / metabolites / Middle Aged / Nutrition research / Obesity - diet therapy / Obesity - metabolism / Obesity - physiopathology / Overweight / Peptides / Propionates - pharmacology / Propionates - therapeutic use / propionic acid / Rest / resting energy expenditure / satiety / Satiety Response - drug effects / Taste / weight gain / Women