Journal Article

Associations between Dietary Acid Load and Biomarkers of Inflammation and Hyperglycemia in Breast Cancer Survivors

Seaver, Phoebe, Pierce, John P., Wu, Tianying, Wang, Emily, Lemus, Hector, Hollenbach, Kathryn

2019

Overview

Metabolic acidosis can lead to inflammation, tissue damage, and cancer metastasis. Dietary acid load contributes to metabolic acidosis if endogenous acid–base balance is not properly regulated. Breast cancer survivors have reduced capacities to adjust their acid–base balance; yet, the associations between dietary acid load and inflammation and hyperglycemia have not been examined among them. We analyzed data collected from 3042 breast cancer survivors enrolled in the Women’s Healthy Eating and Living (WHEL) Study who had provided detailed dietary intakes and measurements of plasma C-reactive protein (CRP) and hemoglobin A1c (HbA1c). Using a cross-sectional design, we found positive associations between dietary acid load and plasma CRP and HbA1c. In the multivariable-adjusted models, compared to women with the lowest quartile, the intakes of dietary acid load among women with the highest quartile showed 30–33% increases of CRP and 6–9% increases of HbA1c. Our study is the first to demonstrate positive associations between dietary acid load and CRP and HbA1c in breast cancer survivors. Our study identifies a novel dietary factor that may lead to inflammation and hyperglycemia, both of which are strong risk factors for breast cancer recurrence and comorbidities.

• Publisher: MDPI AG,MDPI
• Subject: acidosis / Acidosis - blood / Acidosis - diagnosis / Acidosis - etiology / Adolescent / Adult / Aged / Biomarkers / Biomarkers - blood / Blood Glucose - metabolism / Breast cancer / breast neoplasms / Breast Neoplasms - therapy / C-reactive protein / C-Reactive Protein - analysis / cancer recurrence / Cancer Survivors / comorbidity / Cross-Sectional Studies / data analysis / data collection / Diet - adverse effects / enzymes / Female / food intake / Glycated Hemoglobin A - metabolism / glycohemoglobin / healthy eating habits / Humans / Hydrogen-Ion Concentration / Hyperglycemia / Hyperglycemia - blood / Hyperglycemia - diagnosis / Hyperglycemia - etiology / Inflammation / Inflammation - blood / Inflammation - diagnosis / Inflammation - etiology / Inflammation Mediators - blood / metastasis / Middle Aged / Randomized Controlled Trials as Topic / Risk Assessment / Risk Factors / Time Factors / women / Young Adult