Journal Article

Body Fat Changes and Liver Safety in Obese and Overweight Women Supplemented with Conjugated Linoleic Acid: A 12-Week Randomised, Double-Blind, Placebo-Controlled Trial

Walkowiak, Jarosław, Lisowska, Aleksandra, Subramaniapillai, Mehala, Czochralska-Duszyńska, Agata, Miśkiewicz-Chotnicka, Anna, Malesza, Ida Judyta, Mądry, Edyta, Walkowiak, Marek

2020

Overview

Preliminary evidence suggests that conjugated linoleic acid (CLA) may reduce body weight and affect body composition. The present study assessed the effect of CLA supplementation on body fat composition in overweight and obese women, while also evaluating the liver safety of CLA use. Seventy-four obese or overweight women were randomly assigned to receive 3 g/day CLA or placebo for 12 weeks. Body composition (dual-energy X-ray absorptiometry) and liver function (13C-methacetin breath test and serum liver enzymes) were assessed before and after the trial. Patients receiving CLA experienced a significant reduction of total body fat expressed as mass (p = 0.0007) and percentage (p = 0.0006), android adipose tissue (p = 0.0002), gynoid adipose tissue (p = 0.0028), and visceral adipose tissue (p = 4.2 × 10−9) as well as a significant increase in lean body mass to height (p = 6.1 × 10−11) when compared to those receiving a placebo. The maximum momentary 13C recovery changes and end-point values were significantly higher in the CLA group when compared to the placebo group (p = 0.0385 and p = 0.0076, respectively). There were no significant changes in alanine aminotransferase, asparagine aminotransferase, and gamma-glutamyl transpeptidase activities between the groups. In conclusion, CLA supplementation was well tolerated and safe for the liver, which shows beneficial effects on fat composition in overweight and obese women.

• Publisher: MDPI AG,MDPI
• Subject: adipose tissue / Adipose Tissue - drug effects / Adult / alanine transaminase / asparagine / blood serum / Body fat / Body mass index / breath tests / conjugated linoleic acid / Cytochrome / Diabetes / Dietary Supplements / Double-Blind Method / Double-blind studies / dual-energy X-ray absorptiometry / Female / gamma-glutamyltransferase / Gastrointestinal surgery / height / Humans / Laboratories / lean body mass / Linoleic Acids, Conjugated - administration & dosage / Linoleic Acids, Conjugated - therapeutic use / liver / Liver - drug effects / Liver diseases / liver function / Middle Aged / Obesity / Obesity - drug therapy / Overweight / Overweight - drug therapy / placebos / Poland / Sample size / Womens health