Journal Article

PD-1+ immune cell infiltration inversely correlates with survival of operable breast cancer patients

Wang, Jianhua, Wang, Xiumin, Garfield, David H., Jin, Xiaolong, Wang, Jinglong, Mao, Yan, Yuan, Fei, Yu, Qixiang, Fei, Xiaochun, Sun, Shenyou, Shen, Kunwei, Huang, Ou, Sun, Long

2014

Overview

The programmed death-1 (PD-1) molecule is mainly expressed on functionally “exhausted” CD8 + T cells, dampening the host antitumor immune response. We evaluated the ratio between effective and regulatory T cells (Tregs) and PD-1 expression as a prognostic factor for operable breast cancer patients. A series of 218 newly diagnosed invasive breast cancer patients who had undergone primary surgery at Ruijin Hospital were identified. The influence of CD8 + cytotoxic T lymphocytes, FOXP3 + (Treg cell marker), and PD-1 + immune cell counts on prognosis was analyzed utilizing immunohistochemistry. Both PD-1 + immune cells and FOXP3 + Tregs counts were significantly associated with unfavorable prognostic factors. In bivariate, but not multivariate analysis, high tumor infiltrating PD-1 + cell counts correlated with significantly shorter patient survival. Our results suggest a prognostic value of the PD-1 + immune cell population in such breast cancer patients. Targeting the PD-1 pathway may be a feasible approach to treating patients with breast cancer.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adult / Aged / Aged, 80 and over / Antigens, Differentiation, T-Lymphocyte - analysis / Apoptosis - immunology / Breast cancer / Breast Neoplasms - immunology / Breast Neoplasms - mortality / Breast Neoplasms - pathology / Breast Neoplasms - radiotherapy / Breast Neoplasms - surgery / Cancer Research / Carcinoma, Ductal, Breast - immunology / Carcinoma, Ductal, Breast - mortality / Carcinoma, Ductal, Breast - pathology / Carcinoma, Ductal, Breast - radiotherapy / Carcinoma, Ductal, Breast - surgery / Carcinoma, Lobular - immunology / Carcinoma, Lobular - mortality / Carcinoma, Lobular - pathology / Carcinoma, Lobular - radiotherapy / Carcinoma, Lobular - surgery / CD8-Positive T-Lymphocytes - chemistry / CD8-Positive T-Lymphocytes - immunology / CD8-Positive T-Lymphocytes - pathology / Cells / Combined Modality Therapy / Cytokines / Cytotoxicity / Disease-Free Survival / Female / Follow-Up Studies / Forkhead Transcription Factors - analysis / Humans / Immunology / Immunotherapy / Kaplan-Meier Estimate / Lymphocyte Count / Lymphocytes / Lymphocytes, Tumor-Infiltrating - chemistry / Lymphocytes, Tumor-Infiltrating - immunology / Lymphocytes, Tumor-Infiltrating - pathology / Mastectomy / Medical prognosis / Medicine / Medicine & Public Health / Middle Aged / Oncology / Original / Original Article / Patients / Prognosis / Programmed Cell Death 1 Receptor - analysis / Radiotherapy, Adjuvant / Surgery / Survival Analysis / T-Lymphocyte Subsets - chemistry / T-Lymphocyte Subsets - immunology / T-Lymphocyte Subsets - pathology / T-Lymphocytes, Cytotoxic - chemistry / T-Lymphocytes, Cytotoxic - immunology / T-Lymphocytes, Cytotoxic - pathology / T-Lymphocytes, Regulatory - chemistry / T-Lymphocytes, Regulatory - immunology / T-Lymphocytes, Regulatory - pathology / Tumors