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Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma

by Zanotti, Giuseppe , de Bernard, Marina , Farsi, Marco , Cianchi, Fabio , D’Elios, Mario Milco , Kundu, Manikuntala , Bella, Chiara Della , Bencini, Lapo , Niccolai, Elena , Munari, Fabio , Benagiano, Marisa , Emmi, Giacomo , Amedei, Amedeo

in Adenocarcinoma - immunology / Female / Helicobacter pylori / Helicobacter pylori - metabolism / Humans / Im - Original / Inflammation - immunology / Internal Medicine / Male / Medicine / Medicine & Public Health / Middle Aged / Peptidylprolyl Isomerase - biosynthesis / Peptidylprolyl Isomerase - physiology / Stomach Neoplasms - immunology / Th17 Cells - immunology / Tumor Cells, Cultured

2014

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Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma

2014

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Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma

2014

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Journal Article

Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma

Zanotti, Giuseppe,

de Bernard, Marina,

Farsi, Marco,

Cianchi, Fabio,

D’Elios, Mario Milco,

Kundu, Manikuntala,

Bella, Chiara Della,

Bencini, Lapo,

Niccolai, Elena,

Munari, Fabio,

Benagiano, Marisa,

Emmi, Giacomo,

Amedei, Amedeo

2014

Overview

Helicobacter pylori infection is characterized by an inflammatory infiltrate, consisting mainly of neutrophils and T cells. This study was undertaken to evaluate the type of gastric T cell response elicited by the secreted peptidyl prolyl cis , trans -isomerase of H. pylori (HP0175) in patients with distal gastric adenocarcinoma. The cytokine profile and the effector functions of gastric tumor-infiltrating lymphocytes (TILs) specific for HP0175 was investigated in 20 patients with distal gastric adenocarcinoma and H. pylori infection. The helper function of HP0175-specific TILs for monocyte MMP-2, MMP-9, and VEGF production was also investigated. TILs cells from H. pylori infected patients with distal gastric adenocarcinoma produced Interleukin (IL)-17 and IL-21 in response to HP0175. HP0175-specific TILs showed poor cytolytic activity while expressing helper activity for monocyte MMP-2, MMP-9 and VEGF production. These findings indicate that HP0175 is able to drive gastric Th17 response. Thus, HP0175, by promoting pro-inflammatory low cytotoxic TIL response, matrix degradation and pro-angiogenic pathways, may provide a link between H. pylori and gastric cancer.

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Publisher

Springer Milan,Springer Nature B.V

Subject

Adenocarcinoma - immunology

/ Female

/ Helicobacter pylori

/ Helicobacter pylori - metabolism

/ Humans

/ Im - Original

/ Inflammation - immunology