Journal Article

Comparison of non-radiomics imaging features and radiomics models based on contrast-enhanced ultrasound and Gd-EOB-DTPA-enhanced MRI for predicting microvascular invasion in hepatocellular carcinoma within 5 cm

Zheng, Ruiying, Xie, Xiaoyan, Huang, Guangliang, Li, Shurong, Zhang, Xiaoer, Zhang, Yi, Shen, Hui, Liu, Baoxian

2023

Overview

Objectives The purpose of this study is to establish microvascular invasion (MVI) prediction models based on preoperative contrast-enhanced ultrasound (CEUS) and ethoxybenzyl-enhanced magnetic resonance imaging (EOB-MRI) in patients with a single hepatocellular carcinoma (HCC) ≤ 5 cm. Methods Patients with a single HCC ≤ 5 cm and accepting CEUS and EOB-MRI before surgery were enrolled in this study. Totally, 85 patients were randomly divided into the training and validation cohorts in a ratio of 7:3. Non-radiomics imaging features, the CEUS and EOB-MRI radiomics scores were extracted from the arterial phase, portal phase and delayed phase images of CEUS and the hepatobiliary phase images of EOB-MRI. Different MVI predicting models based on CEUS and EOB-MRI were constructed and their predictive values were evaluated. Results Since univariate analysis revealed that arterial peritumoral enhancement on the CEUS image, CEUS radiomics score, and EOB-MRI radiomics score were significantly associated with MVI, three prediction models, namely the CEUS model, the EOB-MRI model, and the CEUS-EOB model, were developed. In the validation cohort, the areas under the receiver operating characteristic curve of the CEUS model, the EOB-MRI model, and the CEUS-EOB model were 0.73, 0.79, and 0.86, respectively. Conclusions Radiomics scores based on CEUS and EOB-MRI, combined with arterial peritumoral enhancement on CEUS, show a satisfying performance of MVI predicting. There was no significant difference in the efficacy of MVI risk evaluation between radiomics models based on CEUS and EOB-MRI in patients with a single HCC ≤ 5 cm. Clinical relevance statement Radiomics models based on CEUS and EOB-MRI are effective for MVI predicting and conducive to pretreatment decision-making in patients with a single HCC within 5 cm. Key Points • Radiomics scores based on CEUS and EOB-MRI, combined with arterial peritumoral enhancement on CEUS, show a satisfying performance of MVI predicting. • There was no significant difference in the efficacy of MVI risk evaluation between radiomics models based on CEUS and EOB-MRI in patients with a single HCC ≤ 5 cm.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Carcinoma, Hepatocellular - pathology / Contrast Media - pharmacology / Decision making / Diagnostic Radiology / Effectiveness / Gadolinium / Gadolinium DTPA - pharmacology / Hepatocellular carcinoma / Humans / Image enhancement / Imaging / Internal Medicine / Interventional Radiology / Liver cancer / Liver Neoplasms - pathology / Magnetic resonance imaging / Magnetic Resonance Imaging - methods / Medical imaging / Medicine / Medicine & Public Health / Microvasculature / Neuroradiology / Patients / Performance prediction / Prediction models / Radiology / Radiomics / Retrospective Studies / Risk assessment / Ultrasonic imaging / Ultrasound