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Sitagliptin protects rat kidneys from acute ischemia- reperfusion injury via upregulation of GLP-1 and GLP-1 receptors
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Sitagliptin protects rat kidneys from acute ischemia- reperfusion injury via upregulation of GLP-1 and GLP-1 receptors
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Journal Article
Sitagliptin protects rat kidneys from acute ischemia- reperfusion injury via upregulation of GLP-1 and GLP-1 receptors
2015
Overview
Aim： Sitagliptin, an oral glucose-lowering agent, has been found to produce cardiovascular protection possibly via anti-inflammatory and anti-atherosclerotic activities of glucagon-like peptide-1 receptor （GLP-1）. The aim of this study was to investigate whether sitagliptin protected the kidney function from acute ischemia-reperfusion （IR） injury in rats. Methods： Adult male SD rats were categorized into 4 groups： sham control, IR injury, IR＋sitagliptin （300 mg/kg） and IR＋sitagliptin （600 mg/kg）. Acute renal IR injury of both kidneys was induced by clamping the renal pedicles for I h. The drug was orally administered at 1, 24 and 48 h after acute IR. Blood samples and 24-h urine were collected before and at 72 h after acute IR. Then the rats were sacrificed, and the kidneys were harvested for biochemical and immunohistochemical studies.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ chronic
/ disease
/ GLP-1
/ Glucagon-Like Peptide 1 - metabolism
/ Glucagon-Like Peptide-1 Receptor
/ injury
/ ischemia
/ kidney
/ Male
/ Original
/ oxygen
/ Rats
/ reactive
/ Receptors, Glucagon - metabolism
/ Reperfusion Injury - drug therapy
/ Reperfusion Injury - metabolism
/ stress
/ Up-Regulation - drug effects
/ Vaccine
