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The Impact of Exercise on Improving Body Composition and PSA in High-Risk Prostate Cancer Patients on Androgen-Deprivation Therapy
by
Lin, Yu-Ching
, Yeh, Kun-Yun
, Juan, Yu-Hsiang
, Shao, I-Hung
, Chen, Chien-Lun
, Hou, Chen-Pang
, Yu, Kai-Jie
, Chen, Liang-Sien
, Lin, Chin-Li
, Chuang, Hai-Hua
in
Abdomen
/ Aged
/ Androgen Antagonists - therapeutic use
/ Androgen suppression therapy
/ Androgens
/ Body Composition
/ Body fat
/ Cancer patients
/ Care and treatment
/ Complications and side effects
/ Exercise Therapy
/ Health aspects
/ Humans
/ Male
/ Middle Aged
/ Nutrition
/ Physiological aspects
/ Prevention
/ Prognosis
/ Prospective Studies
/ Prostate cancer
/ Prostate-Specific Antigen
/ Prostatic Neoplasms - chemically induced
/ Prostatic Neoplasms - drug therapy
/ Risk factors
/ Sarcopenia
/ Testosterone
2022
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The Impact of Exercise on Improving Body Composition and PSA in High-Risk Prostate Cancer Patients on Androgen-Deprivation Therapy
by
Lin, Yu-Ching
, Yeh, Kun-Yun
, Juan, Yu-Hsiang
, Shao, I-Hung
, Chen, Chien-Lun
, Hou, Chen-Pang
, Yu, Kai-Jie
, Chen, Liang-Sien
, Lin, Chin-Li
, Chuang, Hai-Hua
in
Abdomen
/ Aged
/ Androgen Antagonists - therapeutic use
/ Androgen suppression therapy
/ Androgens
/ Body Composition
/ Body fat
/ Cancer patients
/ Care and treatment
/ Complications and side effects
/ Exercise Therapy
/ Health aspects
/ Humans
/ Male
/ Middle Aged
/ Nutrition
/ Physiological aspects
/ Prevention
/ Prognosis
/ Prospective Studies
/ Prostate cancer
/ Prostate-Specific Antigen
/ Prostatic Neoplasms - chemically induced
/ Prostatic Neoplasms - drug therapy
/ Risk factors
/ Sarcopenia
/ Testosterone
2022
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The Impact of Exercise on Improving Body Composition and PSA in High-Risk Prostate Cancer Patients on Androgen-Deprivation Therapy
by
Lin, Yu-Ching
, Yeh, Kun-Yun
, Juan, Yu-Hsiang
, Shao, I-Hung
, Chen, Chien-Lun
, Hou, Chen-Pang
, Yu, Kai-Jie
, Chen, Liang-Sien
, Lin, Chin-Li
, Chuang, Hai-Hua
in
Abdomen
/ Aged
/ Androgen Antagonists - therapeutic use
/ Androgen suppression therapy
/ Androgens
/ Body Composition
/ Body fat
/ Cancer patients
/ Care and treatment
/ Complications and side effects
/ Exercise Therapy
/ Health aspects
/ Humans
/ Male
/ Middle Aged
/ Nutrition
/ Physiological aspects
/ Prevention
/ Prognosis
/ Prospective Studies
/ Prostate cancer
/ Prostate-Specific Antigen
/ Prostatic Neoplasms - chemically induced
/ Prostatic Neoplasms - drug therapy
/ Risk factors
/ Sarcopenia
/ Testosterone
2022
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The Impact of Exercise on Improving Body Composition and PSA in High-Risk Prostate Cancer Patients on Androgen-Deprivation Therapy
Journal Article
The Impact of Exercise on Improving Body Composition and PSA in High-Risk Prostate Cancer Patients on Androgen-Deprivation Therapy
2022
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Overview
This prospective study investigated how exercise impacted chronological changes in anthropometrics, body composition, prostate-specific antigen (PSA) level and prognostic nutrition index (PNI) in high-risk prostate cancer (PCa) patients on androgen deprivation therapy (ADT). The patients were divided into either the usual care or exercise group. All patients received measurements a week before ADT initiation, six- and twelve months after treatment. The exercise group received both aerobic and resistance training. The analysis was conducted using appropriate statistical methods. There were 45 males enrolled (age 67.4 ± 8 years and BMI 25.5 ± 3.6 kg/m2). Profound changes were observed at six months follow-up. The exercise group showed a significant increase in the trunk and leg lean mass, and a lesser loss of total and arm lean mass. A significant decrease in PSA was also observed among the exercise group. PNI and PSA were significantly associated with regional lean mass. Exercise can prevent loss or even increase lean mass in high-risk PCa, especially in the early stage of ADT treatment. Moreover, a strong bond between lean mass and PNI and PSA further underscores the importance of early and continuous exercise interventions.
Publisher
MDPI AG,MDPI
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