Asset Details
Do you wish to reserve the book?
Association of bone turnover markers with glucose metabolism in Chinese population
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Association of bone turnover markers with glucose metabolism in Chinese population
Do you wish to request the book?
Association of bone turnover markers with glucose metabolism in Chinese population
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Association of bone turnover markers with glucose metabolism in Chinese population
2017
Overview
The association between type 2 diabetes （T2DM） and bone metabolism has been discussed previously but is controversial. In this study we aimed to evaluate the association of bone turnover markers with glucose metabolism in Chinese population, in which 919 males and 4171 postmenopausal females in a region of Shanghai were recruited. Anthropometric and biochemical traits related to glucose and bone metabolism were analyzed. Participants were classified according to their glucose tolerance as normal glucose tolerance （NGT）, impaired glucose regulation （IGR） or T2DM. Males and females were analyzed separately, and then associations between bone turnover markers （BTMs） and glucose metabolism were evaluated. The results showed that in females, the serum levels of N-terminal osteocalcin （N-MID）, N-terminal procollagen of type I collagen （PINP） and β-cross-linked C-telopeptide of type I collagen （β-CTX） were significantly decreased in the T2DM group compared to the NGT group （P〈0.01）. When age, body mass index, serum lipids, fat percentage, visceral fat area, subcutaneous fat area, anti-diabetic medicines, PINP, N-MID and β-CTX were included in one logistic model, N-MID （OR [95% CI]： 0.954 [0.932; 0.976]; P=0.0001） was significantly associated with T2DM in females. In females, N-MID was associated with insulin sensitivity and HOMA-β. PINP was significantly associated with HOMA-β, GUTT-ISI, Stumvo first-phase insulin secretion index （STU-1） and Stumvoll second-phase insulin secretion index （STU-2）, but β-CTX was associated only with HOMA-β （β_＋SE： 0.1331±0.0311; P=1.95×10^-5） and GUTI--ISI （β±SE： 0.0727±0.0229; P=0.0015）. In males, N-MID was significantly correlated with HOMA-β （β±SE： 0.3439±0.0633; P=7.75×10^-8）, GUTT-ISI （β±SE： 0.1601±0.0531; P=0.0027） and STU-1 （β±SE： 0.2529±0.1033; P=0.0146）. Significant associations were also detected between 13-CTX and HOMA-β （β＋SE： 0.2736±0.0812; P=0.0009）. This study reveals that BTMs are highly associated with T2DM, insulin sensitivity and beta cell function in both Chinese males and postmenopausal females.
