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Bacillus coagulans TBC169 probiotics for intestinal function recovery after gynecological open surgery: a randomized, double-blind, placebo-controlled trial
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Bacillus coagulans TBC169 probiotics for intestinal function recovery after gynecological open surgery: a randomized, double-blind, placebo-controlled trial
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Journal Article
Bacillus coagulans TBC169 probiotics for intestinal function recovery after gynecological open surgery: a randomized, double-blind, placebo-controlled trial
2025
Overview
Background
Restoration of intestinal function after open surgery remains a significant challenge in gynecological practice.
Bacillus coagulans
TBC169 probiotics may enhance intestinal motility and recovery.
Aim
This randomized controlled trial aimed to evaluate the efficacy and safety of
Bacillus coagulans
TBC169 in promoting intestinal function recovery after gynecological open abdominal surgery.
Method
Patients undergoing open surgery were randomly assigned to high-dose (HDG), conventional-dose (CDG), or placebo-controlled (PCG) groups. The primary outcome was the time to first flatus (TFF). Secondary outcomes included time to first defecation (TFD), time to first bowel sounds (TFBS), duration of hospital stay (DHS), and postoperative complication rate (PCR).
Results
A total of 114 patients were included, with 38 patients allocated to each group. TFF was significantly shorter in the CDG (25.8 h vs. 38.1 h,
P
< 0.001) and the HDG (23.1 h vs. 38.1 h,
P
< 0.001) than the PCG. TFBS was significantly reduced in the CDG (16.1 h vs. 19.3 h,
P
< 0.05) and the HDG (14.3 h vs. 19.3 h,
P
< 0.001). Patients in the HDG had a significantly shorter TFD than the PCG (61.2 h vs. 66.4 h,
P
< 0.05). However, DHS did not differ significantly among the groups. PCR was markedly lower in the CDG (34.2% vs. 68.4%,
P
< 0.01) and HDG (21.1% vs. 68.4%,
P
< 0.001) compared to the PCG. No adverse events were reported across the groups.
Conclusion
Bacillus coagulans
TBC169 accelerates intestinal function recovery and reduces postoperative complications following gynecologic open surgery.
Trial Registration
The study protocol was registered with the China Clinical Trials Registry (ChiCTR2200059518).
Publisher
Springer International Publishing,Springer,Springer Nature B.V
Subject
/ Female
/ Gastrointestinal Motility - drug effects
/ Gastrointestinal Motility - physiology
/ Gynecologic Surgical Procedures - adverse effects
/ Gynecologic Surgical Procedures - trends
/ Humans
/ Medicine
/ Patients
/ Pharmacy
/ Placebos
/ Postoperative Complications - prevention & control
/ Probiotics - administration & dosage
/ Probiotics - adverse effects
/ Recovery of Function - drug effects
/ Recovery of Function - physiology
/ Surgery
