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Device therapy with interatrial shunt devices for heart failure with preserved ejection fraction
by
Kaye, David M
, Nanayakkara, Shane
in
Catheters
/ Comorbidity
/ Congestive heart failure
/ Diabetes
/ Dyspnea
/ Edema
/ Ejection fraction
/ Heart failure
/ Iatrogenesis
/ Intolerance
/ Kinases
/ Morbidity
/ Mortality
/ Pathophysiology
/ Patients
/ Quality of life
/ Workloads
2023
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Device therapy with interatrial shunt devices for heart failure with preserved ejection fraction
by
Kaye, David M
, Nanayakkara, Shane
in
Catheters
/ Comorbidity
/ Congestive heart failure
/ Diabetes
/ Dyspnea
/ Edema
/ Ejection fraction
/ Heart failure
/ Iatrogenesis
/ Intolerance
/ Kinases
/ Morbidity
/ Mortality
/ Pathophysiology
/ Patients
/ Quality of life
/ Workloads
2023
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Device therapy with interatrial shunt devices for heart failure with preserved ejection fraction
by
Kaye, David M
, Nanayakkara, Shane
in
Catheters
/ Comorbidity
/ Congestive heart failure
/ Diabetes
/ Dyspnea
/ Edema
/ Ejection fraction
/ Heart failure
/ Iatrogenesis
/ Intolerance
/ Kinases
/ Morbidity
/ Mortality
/ Pathophysiology
/ Patients
/ Quality of life
/ Workloads
2023
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Device therapy with interatrial shunt devices for heart failure with preserved ejection fraction
Journal Article
Device therapy with interatrial shunt devices for heart failure with preserved ejection fraction
2023
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Overview
Heart failure with preserved ejection fraction is responsible for half of all heart failure and confers substantial morbidity and mortality, and yet to date, there have been no effective pharmacologic interventions. Although the pathophysiology is complex, the primary aetiology of exercise intolerance is due to an elevated left atrial pressure, particularly with exercise. In this context, device-based therapy has become a focus. Several companies have developed techniques to percutaneously create an iatrogenic left to right shunt at the atrial level, thereby reducing left atrial pressure and reducing transmitted pressures to the pulmonary circulation and reducing pulmonary congestion. In this review, we explore the pathophysiology, evidence base, benefits, and considerations of these devices and their place in the therapeutic landscape of heart failure with preserved ejection fraction.
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