Journal Article

Factors associated with muscle function in patients with hematologic malignancies undergoing chemotherapy

Fukushima, Takuya, Nakano, Jiro, Sakamoto, Junya, Okita, Minoru, Ishii, Shun, Miyazaki, Yasushi, Sato, Shuntaro, Natsuzako, Ayumi

2020

Overview

Purpose Muscle dysfunction such as loss of muscle mass and decreased muscle strength is often observed in patients with hematologic malignancies. However, specific factors associated with muscle function have not been identified. The purpose of this study was to identify significant factors affecting muscle function in patients with hematologic malignancies. Methods This was a cross-sectional, observational study. Eighty-eight inpatients with hematologic malignancies undergoing chemotherapy were recruited. Participants were evaluated for muscle thickness and isometric knee extensor strength as indicators of muscle function, physical activity, physical symptoms, psychological distress, and self-efficacy at the start date of rehabilitation. Multiple regression analysis with muscle function as the dependent variable and clinical information and other evaluation items as explanatory variables was performed. Results Lymphocyte count, the geriatric nutritional risk index, and physical activity were significant factors associated with muscle thickness, while physical activity and self-efficacy were significant factors associated with isometric knee extensor strength. Conclusions Nutritional status, physical activity, and self-efficacy were significant factors associated with muscle function in patients with hematologic malignancies. Rehabilitation intervention focusing on improving physical activity and nutritional status should be considered necessary for enhancing muscle function in patients with hematologic malignancies.

• Publisher: Springer Berlin Heidelberg,Springer,Springer Nature B.V
• Subject: Aged / Analysis / Blood cancer / Cancer / Care and treatment / Chemotherapy / Clinical information / Cross-Sectional Studies / Disease management / Exercise / Exercise - physiology / Female / Function / Hematologic Neoplasms - physiopathology / Hematology / Humans / Inpatient care / Lymphocyte Count / Male / Medicine / Medicine & Public Health / Middle Aged / Muscle function / Muscle Hypotonia - physiopathology / Muscle Hypotonia - rehabilitation / Muscle strength / Muscle Strength - physiology / Nursing / Nursing Research / Nutrition / Nutritional status / Nutritional Status - physiology / Observational studies / Older people / Oncology / Original Article / Pain Medicine / Patients / Physical activity / Physical fitness / Physical symptoms / Psychological Distress / Regression analysis / Rehabilitation / Rehabilitation Medicine / Self Efficacy / Stress (Psychology)