Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Sensitivity of anti-SARS-CoV-2 serological assays in a high-prevalence setting

by Mertens, Alexander , Di Cristanziano Veronica , Drexler Ingo , Andree, Marcel , Hermsen, Derik Franz , Boege Friedrich , Schaal Heiner , Senff Tina , Walker, Andreas , Wienemann Tobias , Ostermann, Philipp Niklas , Hauka, Sandra , Keitel Verena , Lübke, Nadine , Timm Jörg , Kaiser, Rolf , Müller, Lisa , Adams, Ortwin , Klein, Florian

in Antibodies / Assaying / COVID-19 / Immunofluorescence / Neutralization / Serological tests / Serology / Severe acute respiratory syndrome coronavirus 2 / Ultrasonic testing

2021

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Sensitivity of anti-SARS-CoV-2 serological assays in a high-prevalence setting

in Antibodies / Assaying / COVID-19 / Immunofluorescence / Neutralization / Serological tests / Serology / Severe acute respiratory syndrome coronavirus 2 / Ultrasonic testing

2021

Confirm

Do you wish to request the book?

Sensitivity of anti-SARS-CoV-2 serological assays in a high-prevalence setting

in Antibodies / Assaying / COVID-19 / Immunofluorescence / Neutralization / Serological tests / Serology / Severe acute respiratory syndrome coronavirus 2 / Ultrasonic testing

2021

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Sensitivity of anti-SARS-CoV-2 serological assays in a high-prevalence setting

Mertens, Alexander,

Di Cristanziano Veronica,

Drexler Ingo,

Andree, Marcel,

Hermsen, Derik Franz,

Boege Friedrich,

Schaal Heiner,

Senff Tina,

Walker, Andreas,

Wienemann Tobias,

Ostermann, Philipp Niklas,

Hauka, Sandra,

Keitel Verena,

Lübke, Nadine,

Timm Jörg,

Kaiser, Rolf,

Müller, Lisa,

Adams, Ortwin,

Klein, Florian

2021

Overview

Evaluation and power of seroprevalence studies depend on the performed serological assays. The aim of this study was to assess four commercial serological tests from EUROIMMUN, DiaSorin, Abbott, and Roche as well as an in-house immunofluorescence and neutralization test for their capability to identify SARS-CoV-2 seropositive individuals in a high-prevalence setting. Therefore, 42 social and working contacts of a German super-spreader were tested. Consistent with a high-prevalence setting, 26 of 42 were SARS-CoV-2 seropositive by neutralization test (NT), and immunofluorescence test (IFT) confirmed 23 of these 26 positive test results (NT 61.9% and IFT 54.8% seroprevalence). Four commercial assays detected anti-SARS-CoV-2 antibodies in 33.3-40.5% individuals. Besides an overall discrepancy between the NT and the commercial assays regarding their sensitivity, this study revealed that commercial SARS-CoV-2 spike-based assays are better to predict the neutralization titer than nucleoprotein-based assays are.

Share this book

Add to My Shelf

Publisher

Springer Nature B.V

Subject