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Endovascular procedures cause transient endothelial injury but do not disrupt mature neointima in Drug Eluting Stents
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Endovascular procedures cause transient endothelial injury but do not disrupt mature neointima in Drug Eluting Stents
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Journal Article
Endovascular procedures cause transient endothelial injury but do not disrupt mature neointima in Drug Eluting Stents
2020
Overview
Extensive application of coronary intravascular procedures has led to the increased need of understanding the injury inflicted to the coronary arterial wall. We aimed to investigate acute and prolonged coronary endothelial injury as a result of guidewire use, repeated intravascular imaging and stenting. These interventions were performed in swine (N = 37) and injury was assessed per coronary segment (n = 81) using an Evans Blue dye-exclusion-test. Scanning electron microscopy and light microscopy were then used to visualize the extent and nature of acute (<4 hours) and prolonged (5 days) endothelial injury. Guidewire and imaging injury was mainly associated with denudation and returned to control levels at 5 days. IVUS and OCT combined (Evans Blue staining 28 ± 16%) did not lead to more acute injury than IVUS alone (33 ± 15%). Stent placement caused most injury (85 ± 4%) and despite early stent re-endothelialization at 5 days, the endothelium proved highly permeable (97 ± 4% at 5 days; p < 0.001 vs acute). Imaging of in-stent neointima at 28 days after stent placement did not lead to neointimal rupture. Guidewire, IVUS and OCT induce acute endothelial cell damage, which does not increase during repeated imaging, and heals within 5 days. Interestingly, endothelial permeability increases 5 days post stenting despite near complete re-endothelialization.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Drug-Eluting Stents - adverse effects
/ Humanities and Social Sciences
/ Implants
/ Neointima - diagnostic imaging
/ Percutaneous Coronary Intervention - adverse effects
/ Percutaneous Coronary Intervention - instrumentation
/ Percutaneous Coronary Intervention - methods
/ Postoperative Complications - etiology
/ Postoperative Complications - pathology
/ Scanning electron microscopy
/ Science
/ Stents
/ Swine
/ Tomography, Optical Coherence - adverse effects
/ Tomography, Optical Coherence - methods
