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Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients
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Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients
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Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients
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Journal Article
Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients
2020
Overview
BackgroundHyperpolarized helium 3 magnetic resonance imaging (3He MRI) is useful for investigating pulmonary physiology of pediatric asthma, but a detailed assessment of the safety profile of this agent has not been performed in children.ObjectiveTo evaluate the safety of 3He MRI in children and adolescents with asthma.Materials and methodsThis was a retrospective observational study. 3He MRI was performed in 66 pediatric patients (mean age 12.9 years, range 8–18 years, 38 male, 28 female) between 2007 and 2017. Fifty-five patients received a single repeated examination and five received two repeated examinations. We assessed a total of 127 3He MRI exams. Heart rate, respiratory rate and pulse oximetry measured oxygen saturation (SpO2) were recorded before, during (2 min and 5 min after gas inhalation) and 1 h after MRI. Blood pressure was obtained before and after MRI. Any subjective symptoms were also noted. Changes in vital signs were tested for significance during the exam and divided into three subject age groups (8–12 years, 13–15 years, 16–18 years) using linear mixed-effects models.ResultsThere were no serious adverse events, but three minor adverse events (2.3%; headache, dizziness and mild hypoxia) were reported. We found statistically significant increases in heart rate and SpO2 after 3He MRI. The youngest age group (8–12 years) had an increased heart rate and a decreased respiratory rate at 2 min and 5 min after 3H inhalation, and an increased SpO2 post MRI.ConclusionThe use of 3He MRI is safe in children and adolescents with asthma.
