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Laser speckle decorrelation time-based platelet function testing in microfluidic system
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Journal Article
Laser speckle decorrelation time-based platelet function testing in microfluidic system
2019
Overview
Platelet aggregation and adhesion are critically involved in both normal hemostasis and thrombosis during vascular injury. Before any surgery, it is important to identify the number of platelets and their functionality to reduce the risk of bleeding; therefore, platelet function testing is a requirement. We introduce a novel evaluation method of assessing platelet function with laser speckle contrast imaging. The speckle decorrelation time (SDT) of the blood flowing through a microfluidic channel chip provides a quantitative measure of platelet aggregation. We compared SDTs of whole blood and platelet-poor blood, i.e., whole blood stripped of its buffy coat region, and found a marked reduction in decorrelation time for platelet-poor blood. The measured SDT of platelet-poor blood was 1.04 ± 0.21 ms, while that of whole blood was 2.64 ± 0.83 ms. To further characterize the sensitivity of our speckle decorrelation time-based platelet function testing (SDT-PFT), we added various agonists involved in platelet aggregation, including adenosine diphosphate (ADP), epinephrine (EPI), and arachidonic acid (AA). In this study, the results show that whole blood with ADP resulted in the largest SDT, followed by whole blood with AA, whole blood with EPI, whole blood without agonist, and platelet-poor blood with or without agonist. These findings show that SDT-PFT has the potential for rapid screening of bleeding disorders and monitoring of anti-platelet therapies with only a small volume of blood.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 692/700
/ Agonists
/ Bleeding
/ Blood
/ Blood Platelets - physiology
/ Blood Platelets - radiation effects
/ Humanities and Social Sciences
/ Humans
/ Lasers
/ Light
/ Microfluidics - instrumentation
/ Platelet Function Tests - instrumentation
/ Platelet Function Tests - methods
/ Science
/ Surgery
