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Audit of antibiotic therapy in surgical neonates in a tertiary hospital in Benin City, Nigeria
by
Aghahowa, SylvesterE
, Osifo, OsarumwenseDavid
in
Anti-Bacterial Agents - therapeutic use
/ Antibiotics
/ Bacteria - classification
/ Bacteria - isolation & purification
/ Bacterial infections
/ Cause of Death
/ Child
/ Children
/ Colleges & universities
/ combinations
/ Cross Infection - drug therapy
/ Cross Infection - microbiology
/ Cross Infection - mortality
/ Drug Therapy, Combination
/ Drug Utilization
/ Female
/ Gastrointestinal surgery
/ Health aspects
/ Hospitals, Teaching
/ Humans
/ Infant, Newborn
/ Infants (Newborn)
/ Male
/ Medical Audit
/ Microbial Sensitivity Tests
/ Mortality
/ Nigeria - epidemiology
/ Pathology
/ Postoperative Care - standards
/ Postoperative Complications - drug therapy
/ Postoperative Complications - microbiology
/ Retrospective Studies
/ Sepsis
/ Standard deviation
/ sub-saharan Africa
/ Surgery
/ surgical neonates
/ Surgical outcomes
/ Surgical Procedures, Operative
/ Surgical Wound Infection - drug therapy
/ Surgical Wound Infection - microbiology
/ Surgical Wound Infection - mortality
/ Teaching hospitals
/ Treatment Outcome
2011
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Audit of antibiotic therapy in surgical neonates in a tertiary hospital in Benin City, Nigeria
by
Aghahowa, SylvesterE
, Osifo, OsarumwenseDavid
in
Anti-Bacterial Agents - therapeutic use
/ Antibiotics
/ Bacteria - classification
/ Bacteria - isolation & purification
/ Bacterial infections
/ Cause of Death
/ Child
/ Children
/ Colleges & universities
/ combinations
/ Cross Infection - drug therapy
/ Cross Infection - microbiology
/ Cross Infection - mortality
/ Drug Therapy, Combination
/ Drug Utilization
/ Female
/ Gastrointestinal surgery
/ Health aspects
/ Hospitals, Teaching
/ Humans
/ Infant, Newborn
/ Infants (Newborn)
/ Male
/ Medical Audit
/ Microbial Sensitivity Tests
/ Mortality
/ Nigeria - epidemiology
/ Pathology
/ Postoperative Care - standards
/ Postoperative Complications - drug therapy
/ Postoperative Complications - microbiology
/ Retrospective Studies
/ Sepsis
/ Standard deviation
/ sub-saharan Africa
/ Surgery
/ surgical neonates
/ Surgical outcomes
/ Surgical Procedures, Operative
/ Surgical Wound Infection - drug therapy
/ Surgical Wound Infection - microbiology
/ Surgical Wound Infection - mortality
/ Teaching hospitals
/ Treatment Outcome
2011
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Audit of antibiotic therapy in surgical neonates in a tertiary hospital in Benin City, Nigeria
by
Aghahowa, SylvesterE
, Osifo, OsarumwenseDavid
in
Anti-Bacterial Agents - therapeutic use
/ Antibiotics
/ Bacteria - classification
/ Bacteria - isolation & purification
/ Bacterial infections
/ Cause of Death
/ Child
/ Children
/ Colleges & universities
/ combinations
/ Cross Infection - drug therapy
/ Cross Infection - microbiology
/ Cross Infection - mortality
/ Drug Therapy, Combination
/ Drug Utilization
/ Female
/ Gastrointestinal surgery
/ Health aspects
/ Hospitals, Teaching
/ Humans
/ Infant, Newborn
/ Infants (Newborn)
/ Male
/ Medical Audit
/ Microbial Sensitivity Tests
/ Mortality
/ Nigeria - epidemiology
/ Pathology
/ Postoperative Care - standards
/ Postoperative Complications - drug therapy
/ Postoperative Complications - microbiology
/ Retrospective Studies
/ Sepsis
/ Standard deviation
/ sub-saharan Africa
/ Surgery
/ surgical neonates
/ Surgical outcomes
/ Surgical Procedures, Operative
/ Surgical Wound Infection - drug therapy
/ Surgical Wound Infection - microbiology
/ Surgical Wound Infection - mortality
/ Teaching hospitals
/ Treatment Outcome
2011
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Audit of antibiotic therapy in surgical neonates in a tertiary hospital in Benin City, Nigeria
Journal Article
Audit of antibiotic therapy in surgical neonates in a tertiary hospital in Benin City, Nigeria
2011
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Overview
To report the outcome of commonly used antibiotic combinations in surgical neonates in sub-Saharan African settings.
A retrospective analysis that determines the outcome of commonly combined antibiotics in surgical neonates between January 2006 and December 2008 at two referral paediatric surgical centres in Benin city was carried out.
Ampicillin ampiclox, metronidazole, gentamicin, cefuroxime and ceftriaxone were variously combined in the management of 161 neonates with a mean age at presentation of 9.2 ± 2.6 days, mean weight 3.1 ± 1.4 kg and a male:female ratio 1.6:1. Polymicrobial postoperative wound infections and sepsis caused by Staphylococcus aureus, Escherichia coli, Neisseria meningitidis, Klebsiella pneumonia, Pseudomonas aeroginosa and anaerobes, were mainly encountered. The most common aerobes isolated from wound cultures were S. aureus and P. aeroginosa while the ones from that of blood cultures were E. coli and K. pneumonia. Overall postoperative infections recorded were: wound infection 19 (11.8%), sepsis 16 (9.9%) and sepsis-related deaths 6 (3.7%).
Combinations of gentamicin/metronidazole/cefuroxime and gentamicin/cefuroxime were adequate for gastrointestinal and extra-gastrointestinal neonatal operations, respectively, in these sub-Saharan African settings, which may be useful in similar regions.
Publisher
Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Wolters Kluwer Medknow Publications
Subject
Anti-Bacterial Agents - therapeutic use
/ Bacteria - isolation & purification
/ Child
/ Children
/ Cross Infection - drug therapy
/ Cross Infection - microbiology
/ Female
/ Humans
/ Male
/ Postoperative Care - standards
/ Postoperative Complications - drug therapy
/ Postoperative Complications - microbiology
/ Sepsis
/ Surgery
/ Surgical Procedures, Operative
/ Surgical Wound Infection - drug therapy
/ Surgical Wound Infection - microbiology
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