Asset Details
Do you wish to reserve the book?
Prognosis of aggressive adult T-cell leukemia/lymphoma with central nervous system infiltration and utility of CD7 versus CADM1 flowcytometric plots of cerebrospinal fluid
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Prognosis of aggressive adult T-cell leukemia/lymphoma with central nervous system infiltration and utility of CD7 versus CADM1 flowcytometric plots of cerebrospinal fluid
Do you wish to request the book?
Prognosis of aggressive adult T-cell leukemia/lymphoma with central nervous system infiltration and utility of CD7 versus CADM1 flowcytometric plots of cerebrospinal fluid
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Prognosis of aggressive adult T-cell leukemia/lymphoma with central nervous system infiltration and utility of CD7 versus CADM1 flowcytometric plots of cerebrospinal fluid
2025
Overview
The prognosis of adult T-cell leukemia/lymphoma (ATL) with primary central nervous system (CNS) involvement has been unclear since the advent of new therapies. Recently, we have shown that flow cytometric CD7/CADM1 analysis of CD4 + cells (HAS-Flow) is useful to detect ATL cells that are not morphologically diagnosed as ATL cells. We investigated the role of CNS involvement in ATL using cytology and HAS-Flow by analyzing cerebrospinal fluid (CSF) from 73 aggressive ATL cases. Based on the findings in CSF, the study subjects were classified into CNS + (cytologically malignant,
n
= 18), CNS- (cytologically non-malignant and ATL cell population negative in HAS-Flow,
n
= 44), and CNS-Micro (cytologically non-malignant and ATL cell population positive in HAS-Flow,
n
= 11) groups. As expected, the CNS + group had a shorter overall survival than the CNS- groups (
P
< 0.001). However, the CNS-Micro group showed no adverse impact on overall survival compared to the CNS- group (
P
= 0.506), even without additional CNS-targeted treatments. HAS-Flow also demonstrated clinical utility in the diagnosis of CSF lesions in ATL patients with cerebral white matter lesions and in the detection of ATL cells on post-treatment CSF examination in patients with CNS involvement. Our study demonstrates that ATL with CNS involvement have a poor prognosis and that CSF HAS-Flow is useful to assist in the diagnosis of suspected CNS involvement and to detect ATL cells with high sensitivity after treatment.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Aged
/ Antigens, CD7 - cerebrospinal fluid
/ Cell Adhesion Molecule-1 - cerebrospinal fluid
/ Central Nervous System Neoplasms - cerebrospinal fluid
/ Central Nervous System Neoplasms - diagnosis
/ Central Nervous System Neoplasms - mortality
/ Female
/ Humans
/ Leukemia
/ Leukemia-Lymphoma, Adult T-Cell - cerebrospinal fluid
/ Leukemia-Lymphoma, Adult T-Cell - diagnosis
/ Leukemia-Lymphoma, Adult T-Cell - mortality
/ Leukemia-Lymphoma, Adult T-Cell - pathology
/ Lymphoma
/ Male
/ Medicine
/ Oncology
