Journal Article

Acquired bilateral facial palsy: a systematic review on aetiologies and management

Rinaldi, Rita, Barbazza, Alice, Fernandez, Ignacio Javier, Lami, Federico, D’Angelo, Roberto, Botti, Cecilia, Alicandri-Ciufelli, Matteo, Molinari, Giulia, Federici, Gaia, Presutti, Livio, Lucidi, Daniela, Vanelli, Elena

2023

Overview

Objective To systematically review the published cases of bilateral facial palsy (BFP) to gather evidence on the clinical assessment and management of this pathology. Methods Following PRISMA statement recommendations, 338 abstracts were screened independently by two authors. Inclusion criteria were research articles of human patients affected by BFP, either central or peripheral; English, Italian, French or Spanish language; availability of the abstract, while exclusion criteria were topics unrelated to FP, and mention of unilateral or congenital FP. Only full-text articles reporting the diagnostic work-up, the management, and the prognosis of the BFP considered for further specific data analysis. Results A total of 143 articles were included, resulting a total of 326 patients with a mean age of 36 years. The most common type of the paralysis was peripheral (91.7%), and the autoimmune disease was the most frequent aetiology (31.3%). The mean time of onset after first symptoms was 12 days and most patients presented with a grade higher than III. Associated symptoms in idiopathic BFP were mostly non-specific. The most frequently positive laboratory exams were cerebrospinal fluid analysis, autoimmune screening and peripheral blood smear, and the most performed imaging was MRI. Most patients (74%) underwent exclusive medical treatment, while a minority were selected for a surgical or combined approach. Finally, in more than half of cases a complete bilateral recovery (60.3%) was achieved. Conclusions BFP is a disabling condition. If a correct diagnosis is formulated, possibilities to recover are elevated and directly correlated to the administration of an adequate treatment.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adult / Autoimmune diseases / Case reports / Causality / Cerebrospinal fluid / Congenital diseases / Data analysis / Disease / Facial Nerve Diseases / Facial paralysis / Facial Paralysis - diagnosis / Facial Paralysis - etiology / Facial Paralysis - therapy / Humans / Iatrogenesis / Magnetic Resonance Imaging / Medical treatment / Medicine / Medicine & Public Health / Metabolism / Neurology / Neuroradiology / Neurosciences / Otolaryngology / Paralysis / Patients / Peripheral blood / Review / Spanish language / Systematic review