Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

by Punwani, Shonit , Harries, Lorna , Islam, Khirul , Singh, Saurabh , Haider, Aiman , Maitland, Norman J. , Leivo, Janne , Whitaker, Hayley , Crundwell, Malcolm , Sharp, Adam , Stopka-Farooqui, Urszula , Daugaard, Mads , Calle, Beatriz , Hodgson, Kirsty , Elliott, David J. , Hysenaj, Gerald , Flohr, Penny , Arredondo, Hector M. , Kelly, Lois , Gray, Melissa Anne , de Bono, Johann , Roustan, Chloe , McClurg, Urszula L. , Thomas, Huw , Turner, Helen , Fowler, Gemma , Frame, Fiona M. , Goode, Emily Archer , Scott, Emma , Bogdan, Denisa , Schumann, Benjamin , Garnham, Rebecca , Bermudez, Abel , Knight, Bridget , Munkley, Jennifer , McCullagh, Paul , Oo, Htoo Zarni , Yuan, Wei , Bastian, Kayla , Duxfield, Adam , McGrath, John , Cheung, Kathleen , Pye, Hayley , Westaby, Daniel , Tolson, Aaron , Mellor, Ellie , Guerrero, Ramon Hurtado , Wang, Ning , Heer, Rakesh , Bertozzi, Carolyn R. , Heavey, Susan , Wisnovsky, Simon , Wilson, Laura , Johnston, Edward W. , Pitteri, Sharon , Marques, Fernando Jose Garcia , Orozco-Moreno, Margarita , Yo, Edward Christopher , Freeman, Alex

in 101/58 / 13/105 / 631/67/589/466 / 631/80/221 / 631/80/83 / 692/53/2421 / 82/51 / Apoptosis / Cell Biology / Cell cycle / Glycosylation / Glycosyltransferase / Human Genetics / Humans / Internal Medicine / Male / Medicine / Medicine & Public Health / Metastases / Oncology / Prostate cancer / Prostatic Neoplasms - metabolism / Signal Transduction / Transcriptional Activation / Tumors / Up-Regulation

2023

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

2023

Confirm

Do you wish to request the book?

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

2023

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

Punwani, Shonit,

Harries, Lorna,

Islam, Khirul,

Singh, Saurabh,

Haider, Aiman,

Maitland, Norman J.,

Leivo, Janne,

Whitaker, Hayley,

Crundwell, Malcolm,

Sharp, Adam,

Stopka-Farooqui, Urszula,

Daugaard, Mads,

Calle, Beatriz,

Hodgson, Kirsty,

Elliott, David J.,

Hysenaj, Gerald,

Flohr, Penny,

Arredondo, Hector M.,

Kelly, Lois,

Gray, Melissa Anne,

de Bono, Johann,

Roustan, Chloe,

McClurg, Urszula L.,

Thomas, Huw,

Turner, Helen,

Fowler, Gemma,

Frame, Fiona M.,

Goode, Emily Archer,

Scott, Emma,

Bogdan, Denisa,

Schumann, Benjamin,

Garnham, Rebecca,

Bermudez, Abel,

Knight, Bridget,

Munkley, Jennifer,

McCullagh, Paul,

Oo, Htoo Zarni,

Yuan, Wei,

Bastian, Kayla,

Duxfield, Adam,

McGrath, John,

Cheung, Kathleen,

Pye, Hayley,

Westaby, Daniel,

Tolson, Aaron,

Mellor, Ellie,

Guerrero, Ramon Hurtado,

Wang, Ning,

Heer, Rakesh,

Bertozzi, Carolyn R.,

Heavey, Susan,

Wisnovsky, Simon,

Wilson, Laura,

Johnston, Edward W.,

Pitteri, Sharon,

Marques, Fernando Jose Garcia,

Orozco-Moreno, Margarita,

Yo, Edward Christopher,

Freeman, Alex

2023

Overview

Prostate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains an unmet clinical need to improve how clinically significant prostate cancer is diagnosed and develop new treatments for advanced disease. Aberrant glycosylation is a hallmark of cancer implicated in tumour growth, metastasis, and immune evasion. One of the key drivers of aberrant glycosylation is the dysregulated expression of glycosylation enzymes within the cancer cell. Here, we demonstrate using multiple independent clinical cohorts that the glycosyltransferase enzyme GALNT7 is upregulated in prostate cancer tissue. We show GALNT7 can identify men with prostate cancer, using urine and blood samples, with improved diagnostic accuracy than serum PSA alone. We also show that GALNT7 levels remain high in progression to castrate-resistant disease, and using in vitro and in vivo models, reveal that GALNT7 promotes prostate tumour growth. Mechanistically, GALNT7 can modify O -glycosylation in prostate cancer cells and correlates with cell cycle and immune signalling pathways. Our study provides a new biomarker to aid the diagnosis of clinically significant disease and cements GALNT7-mediated O -glycosylation as an important driver of prostate cancer progression.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ 13/105

/ 82/51