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Journal Article
“Cardiac glycosides”—quo vaditis?—past, present, and future?
2024
Overview
Up to date, digitalis glycosides, also known as “cardiac glycosides”, are inhibitors of the Na
+
/K
+
-ATPase. They have a long-standing history as drugs used in patients suffering from heart failure and atrial fibrillation despite their well-known narrow therapeutic range and the intensive discussions on their raison d’être for these indications. This article will review the history and key findings in basic and clinical research as well as potentially overseen pros and cons of these drugs.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Animals
/ Atrial Fibrillation - drug therapy
/ Biomedical and Life Sciences
/ Cardiac Glycosides - pharmacology
/ Cardiac Glycosides - therapeutic use
/ Digitalis Glycosides - history
/ Digitalis Glycosides - pharmacology
/ Digitalis Glycosides - therapeutic use
/ Drugs
/ Enzymes
/ Heart Failure - drug therapy
/ Humans
/ Kinases
/ Review
/ Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors
/ Sodium-Potassium-Exchanging ATPase - metabolism
/ Toxicity
