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Long-Term Cognitive Impairment after Critical Illness

by Ely, E.W , Geevarghese, S.K , Pandharipande, P.P , Shintani, A.K , Vasilevskis, E.E , Morandi, A , Girard, T.D , Pun, B.T , Hopkins, R.O , Brummel, N.E , Moons, K.G , Thompson, J.L , Jackson, J.C , Hughes, C.G , Bernard, G.R , Dittus, R.S , Canonico, A

in Age / Aged / Alzheimer's disease / Analgesics / Anesthesia / Biological and medical sciences / Brain research / Cognition & reasoning / Cognition Disorders - etiology / Cognitive ability / Consciousness / Consent / Critical Illness - psychology / Delirium / Delirium - complications / Dementia / Education / Executive Function / Female / General aspects / Hospitalization / Hospitals / Humans / Illnesses / Intensive Care Units / Linear Models / Male / Medical sciences / Middle Aged / Neurodegenerative diseases / Older people / Prospective Studies / R&D / Research & development / Respiratory failure / Respiratory Insufficiency - complications / Risk factors / Shock - complications / Traumatic brain injury

2013

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2013

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2013

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Journal Article

Long-Term Cognitive Impairment after Critical Illness

Ely, E.W,

Geevarghese, S.K,

Pandharipande, P.P,

Shintani, A.K,

Vasilevskis, E.E,

Morandi, A,

Girard, T.D,

Pun, B.T,

Hopkins, R.O,

Brummel, N.E,

Moons, K.G,

Thompson, J.L,

Jackson, J.C,

Hughes, C.G,

Bernard, G.R,

Dittus, R.S,

Canonico, A

2013

Overview

In this study, patients treated in ICUs were at high risk for new cognitive impairment during 12 months of follow-up, with 24% of patients having deficits similar in severity to those in Alzheimer's disease. A longer duration of delirium was associated with worse cognitive scores. Survivors of critical illness frequently have a prolonged and poorly understood form of cognitive dysfunction, 1 – 4 which is characterized by new deficits (or exacerbations of preexisting mild deficits) in global cognition or executive function. This long-term cognitive impairment after critical illness may be a growing public health problem, given the large number of acutely ill patients being treated in intensive care units (ICUs) globally. 5 Among older adults, cognitive decline is associated with institutionalization, 6 hospitalization, 7 and considerable annual societal costs. 8 , 9 Yet little is known about the epidemiology of long-term cognitive impairment after critical illness. Delirium, a form of acute brain . . .

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Publisher

Massachusetts Medical Society

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Age

/ Aged

/ Alzheimer's disease

/ Analgesics

/ Anesthesia

/ Biological and medical sciences

/ Brain research