Journal Article

Success Predictors of Endoscopic Sleeve Gastroplasty

Di Santo, Riccardo, Matteo, Maria Valeria, Ciasca, Gabriele, Spada, Cristiano, Bove, Vincenzo, Carlino, Giorgio, Vinti, Laila, Boškoski, Ivo, Papi, Massimiliano, Polidori, Giulia, Pontecorvi, Valerio

2024

Overview

Objective Endoscopic sleeve gastroplasty (ESG) is a minimally invasive procedure that proved to be safe and effective in obesity treatment. However, not all subjects respond to treatment in the same way, and, with a view to personalized care, it is essential to identify predictors of success or failure. Methods A retrospective 2-year followed-up cohort of ESG subjects was analyzed to investigate the presence of any baseline or early indicators of long-term optimal or suboptimal ESG outcomes. Results A total of 315 subjects (73% women) were included, with 73% of patients exhibiting an Excess weight loss percentage (%EWL) >25% at the 24 months. Neither demographic parameters (age and sex), smoking habits, and menopause in women nor the presence of comorbidities proved potential predictive value. Interestingly, the %EWL at 1 month after ESG was the strongest predictor of 24-month therapeutic success. Subsequently, we estimated an “early threshold for success” for 1 month-%EWL by employing Youden’s index method. Conclusions ESG is a safe and effective bariatric treatment that can be offered to a wide range of subjects. Early weight loss seems to impact long-term ESG results significantly and may allow proper early post-operative care optimization. Graphical Abstract

• Publisher: Springer US,Springer Nature B.V
• Subject: Body mass index / Diabetes / Endoscopy / Ethics / Females / Gastrointestinal surgery / Lifestyles / Males / Medicine / Medicine & Public Health / Metabolism / Multidisciplinary teams / Obesity / Original Contributions / Postoperative period / Quality of life / Success / Surgery / Sutures / Trends / Weight control