Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Rapid and sensitive protein complex alignment with Foldseek-Multimer

by Steinegger, Martin , Söding, Johannes , Kim, Woosub , Levy Karin, Eli , Mirdita, Milot , Schweke, Hugo , Gilchrist, Cameron L. M. , Levy, Emmanuel D.

in 631/114/2398 / 631/114/663 / 631/114/794 / Algorithms / Alignment / Bioinformatics / Biological Microscopy / Biological Techniques / Biology / Biomedical and Life Sciences / Biomedical Engineering/Biotechnology / Brief Communication / Clustering / Computational Biology - methods / Databases, Protein / Life Sciences / Models, Molecular / Open source software / Protein Conformation / Proteins / Proteins - chemistry / Proteomics / Sequence Alignment - methods / Software

2025

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Rapid and sensitive protein complex alignment with Foldseek-Multimer

by Steinegger, Martin , Söding, Johannes , Kim, Woosub , Levy Karin, Eli , Mirdita, Milot , Schweke, Hugo , Gilchrist, Cameron L. M. , Levy, Emmanuel D.

2025

Confirm

Do you wish to request the book?

Rapid and sensitive protein complex alignment with Foldseek-Multimer

by Steinegger, Martin , Söding, Johannes , Kim, Woosub , Levy Karin, Eli , Mirdita, Milot , Schweke, Hugo , Gilchrist, Cameron L. M. , Levy, Emmanuel D.

2025

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Rapid and sensitive protein complex alignment with Foldseek-Multimer

Steinegger, Martin,

Söding, Johannes,

Kim, Woosub,

Levy Karin, Eli,

Mirdita, Milot,

Schweke, Hugo,

Gilchrist, Cameron L. M.,

Levy, Emmanuel D.

2025

Overview

Advances in computational structure prediction will vastly augment the hundreds of thousands of currently available protein complex structures. Translating these into discoveries requires aligning them, which is computationally prohibitive. Foldseek-Multimer computes complex alignments from compatible chain-to-chain alignments, identified by efficiently clustering their superposition vectors. Foldseek-Multimer is 3–4 orders of magnitudes faster than the gold standard, while producing comparable alignments; this allows it to compare billions of complex pairs in 11 h. Foldseek-Multimer is open-source software available at GitHub via https://github.com/steineggerlab/foldseek/ , https://search.foldseek.com/search/ and the BFMD database. Foldseek-Multimer offers a fast strategy for complex-to-complex alignment to quickly identify compatible sets of chain-to-chain alignments by their superpositions. It can compare billions of complex pairs in 11 h.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group US,Nature Publishing Group

Subject

/ Biological Microscopy