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Structures of human primosome elongation complexes
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Structures of human primosome elongation complexes
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Journal Article
Structures of human primosome elongation complexes
2023
Overview
The synthesis of RNA–DNA primer by primosome requires coordination between primase and DNA polymerase α subunits, which is accompanied by unknown architectural rearrangements of multiple domains. Using cryogenic electron microscopy, we solved a 3.6 Å human primosome structure caught at an early stage of RNA primer elongation with deoxynucleotides. The structure confirms a long-standing role of primase large subunit and reveals new insights into how primosome is limited to synthesizing short RNA–DNA primers.
Here, the authors solve the cryogenic electron microscopy structure of a human primosome to shed light on the mechanism by which RNA–DNA primers are synthesized for the initiation of DNA replication and the structural basis of the primer length limitation.
