Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Neonatal nephrotoxic medication exposure and early acute kidney injury: results from the AWAKEN study

by Sarkar, Subrata , Ohls, Robin , Goldstein, Stuart L , Fuloria, Mamta , Askenazi, David , Mian, Ayesa , Brophy, Patrick D , Raina, Rupesh , Rademacher, Erin , Woroniecki, Robert , Revenis, Mary , Bonachea, Elizabeth , Khokhar, Surender , Nada, Arwa , Chishti, Aftab S , Smith, Alexandra , Steflik, Heidi J , DuPont, Tara , D’Angio, Carl , Ingraham, Susan , Kumar, Deepak , Soranno, Danielle E , Cole, F. Sessions , Hingorani, Sangeeta , Colaizy, Tarah T , Bhutada, Alok , Staples, Amy , Charlton, Jennifer R , Gist, Katja M , Briley, Meagan , Synnes, Anne , Davis, T. Keefe , Mammen, Cherry , Wintermark, Pia , Rohatgi, Smriti , Mhanna, Maroun J , Ambalavanan, Namasivayam , Fletcher, Jeffery , Griffin, Russell , Wazir, Sanjay , Swanson, Jonathan R , Starr, Michelle , Kaskel, Frederick J , Guillet, Ronnie , Jetton, Jennifer , Sethi, Sidharth K , Wong, Craig S , Mahan, John , Abitbol, Carolyn L , Reidy, Kimberly , Gien, Jason , Kent, Alison , DeFreitas, Marissa , Kupferman, Juan C , Milner, Lawrence , Duara, Shahnaz , Selewski, David T , Arikan, Ayse Akcan , Ray, Patricio E , Joseph, Catherine , Sridhar, Shanthy , Nathan, Amy T , Rhee, Christopher J , Hanna, Mina H , Perazzo, Sofia , Dow

in Aminoglycosides / Drugs / Exposure / Human exposure / Intensive care / Kidneys / Neonatal care / Neonates / Newborn babies / Secondary analysis / Toxicity

2023

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Neonatal nephrotoxic medication exposure and early acute kidney injury: results from the AWAKEN study

in Aminoglycosides / Drugs / Exposure / Human exposure / Intensive care / Kidneys / Neonatal care / Neonates / Newborn babies / Secondary analysis / Toxicity

2023

Confirm

Do you wish to request the book?

Neonatal nephrotoxic medication exposure and early acute kidney injury: results from the AWAKEN study

in Aminoglycosides / Drugs / Exposure / Human exposure / Intensive care / Kidneys / Neonatal care / Neonates / Newborn babies / Secondary analysis / Toxicity

2023

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Neonatal nephrotoxic medication exposure and early acute kidney injury: results from the AWAKEN study

Sarkar, Subrata,

Ohls, Robin,

Goldstein, Stuart L,

Fuloria, Mamta,

Askenazi, David,

Mian, Ayesa,

Brophy, Patrick D,

Raina, Rupesh,

Rademacher, Erin,

Woroniecki, Robert,

Revenis, Mary,

Bonachea, Elizabeth,

Khokhar, Surender,

Nada, Arwa,

Chishti, Aftab S,

Smith, Alexandra,

Steflik, Heidi J,

DuPont, Tara,

D’Angio, Carl,

Ingraham, Susan,

Kumar, Deepak,

Soranno, Danielle E,

Cole, F. Sessions,

Hingorani, Sangeeta,

Colaizy, Tarah T,

Bhutada, Alok,

Staples, Amy,

Charlton, Jennifer R,

Gist, Katja M,

Briley, Meagan,

Synnes, Anne,

Davis, T. Keefe,

Mammen, Cherry,

Wintermark, Pia,

Rohatgi, Smriti,

Mhanna, Maroun J,

Ambalavanan, Namasivayam,

Fletcher, Jeffery,

Griffin, Russell,

Wazir, Sanjay,

Swanson, Jonathan R,

Starr, Michelle,

Kaskel, Frederick J,

Guillet, Ronnie,

Jetton, Jennifer,

Sethi, Sidharth K,

Wong, Craig S,

Mahan, John,

Abitbol, Carolyn L,

Reidy, Kimberly,

Gien, Jason,

Kent, Alison,

DeFreitas, Marissa,

Kupferman, Juan C,

Milner, Lawrence,

Duara, Shahnaz,

Selewski, David T,

Arikan, Ayse Akcan,

Ray, Patricio E,

Joseph, Catherine,

Sridhar, Shanthy,

Nathan, Amy T,

Rhee, Christopher J,

Hanna, Mina H,

Perazzo, Sofia,

Dow

2023

Overview

BackgroundWe aimed to describe nephrotoxic medication exposure and investigate associations between exposure and acute kidney injury (AKI) in the neonatal intensive care unit during the first postnatal week.Design/methodsSecondary analysis of the AWAKEN cohort. We evaluated nephrotoxic medication exposure during the first postnatal week and associations with AKI using time-varying Cox proportional hazard regressions models. Nephrotoxic medication exposure categories were defined as: no nephrotoxic medication, nephrotoxic medications excluding aminoglycosides, aminoglycoside alone, and aminoglycoside and another nephrotoxic medication.ResultsOf 2162 neonates, 1616 (74.7%) received ≥1 nephrotoxic medication. Aminoglycoside receipt was most common (72%). AKI developed in 211(9.8%) neonates and was associated with a nephrotoxic medication exposure (p < 0.01). Nephrotoxic medication exposures including a nephrotoxic medication excluding aminoglycoside (aHR 3.14, 95% CI 1.31–7.55) and aminoglycoside and another nephrotoxic medication (aHR 4.79, 95% CI 2.19–10.50) were independently associated with AKI and severe AKI (stage 2/3), respectively.ConclusionsNephrotoxic medication exposure in critically ill infants is common during the first postnatal week. Specific nephrotoxic medication exposure, principally aminoglycosides with another nephrotoxic medication, are independently associated with early AKI.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group

Subject

/ Drugs

/ Kidneys