Asset Details
Do you wish to reserve the book?
Neurofunctional Correlates of Emotional Dysregulation: Systematic Review and ALE Meta‐Analysis
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Neurofunctional Correlates of Emotional Dysregulation: Systematic Review and ALE Meta‐Analysis
Do you wish to request the book?
Neurofunctional Correlates of Emotional Dysregulation: Systematic Review and ALE Meta‐Analysis
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Neurofunctional Correlates of Emotional Dysregulation: Systematic Review and ALE Meta‐Analysis
2026
Overview
Background Emotional dysregulation (ED) is a transdiagnostic feature of several psychiatric and neurodevelopmental disorders, characterized by heightened emotional reactivity, mood instability, and difficulties regulating emotional responses. Methods In this study, an activation likelihood estimation (ALE) meta‐analysis was conducted to examine the neural underpinnings of ED across different clinical populations. A systematic search based on preferred reporting items for systematic reviews and meta‐analyses (PRISMA) guidelines identified 35 task‐based fMRI studies (n = 1989 subjects), including patients with borderline personality disorder (BPD), attention‐deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), and other conditions. Results Hyper‐activation was observed in emotion‐related regions, particularly bilateral amygdala and left insula, indicating heightened emotional sensitivity and reactivity. Hypo‐activation, detected through Bayesian thresholding, was found in areas such as the anterior cingulate cortex and supplementary motor area, suggesting impairments in cognitive control and emotional regulation. Functional connectivity analysis revealed distinct patterns of coactivation, with the amygdala showing isolated activity and the left insula coactivating with regions related to sensory processing and cognitive control. Conclusions These findings provide new insights into the neural circuitry of transdiagnostic ED and suggest that disorders, such as BPD, ADHD, and BD, share common neural mechanisms, particularly in regions involved in emotional reactivity and cognitive regulation. The results have important clinical implications for developing targeted interventions to address both emotional and cognitive deficits in ED. Future research should explore causal mechanisms and incorporate diverse clinical populations to further understand neurobiological basis of ED.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
activation likelihood estimation (ALE) meta‐analysis
/ Affective Symptoms - diagnostic imaging
/ Affective Symptoms - physiopathology
/ Attention Deficit Disorder with Hyperactivity - physiopathology
/ Bipolar Disorder - physiopathology
/ Borderline Personality Disorder - physiopathology
/ Emotional Regulation - physiology
/ Emotions
/ fMRI
/ Humans
/ Neurodevelopmental disorders
/ Review
