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The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease
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The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease
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Journal Article
The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease
2017
Overview
The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.
Publisher
Future Medicine Ltd
Subject
/ alpha-Synuclein - cerebrospinal fluid
/ Autopsy
/ biofluid
/ Biomarkers - cerebrospinal fluid
/ Biopsy
/ Blood
/ Dopamine Plasma Membrane Transport Proteins - metabolism
/ Humans
/ Parkinson Disease - diagnosis
/ Parkinson Disease - pathology
/ Sampling
/ Skin
/ Submandibular Gland - metabolism
/ Submandibular Gland - pathology
/ tissue
