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Stability of global methylation profiles of whole blood and extracted DNA under different storage durations and conditions

by Pan, Xiaoqing , Liu, Pengyuan , Mattson, David L , Cowley, Allen W , Roberts, Michelle L , Li, Yingchuan , Kotchen, Theodore A , Liu, Yong , Kidambi, Srividya , Liang, Mingyu

in Alzheimer's disease / Anticoagulants / Bisulfite / Blood / Brain research / Comparative studies / Deoxyribonucleic acid / DNA / DNA methylation / DNA sequencing / Epigenetics / Gene expression / Genomes / Hypertension / Leukemia / Library collections / methylation profiles / stability / Storage conditions / Storage temperature / Studies

2018

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Stability of global methylation profiles of whole blood and extracted DNA under different storage durations and conditions

by Pan, Xiaoqing , Liu, Pengyuan , Mattson, David L , Cowley, Allen W , Roberts, Michelle L , Li, Yingchuan , Kotchen, Theodore A , Liu, Yong , Kidambi, Srividya , Liang, Mingyu

2018

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Stability of global methylation profiles of whole blood and extracted DNA under different storage durations and conditions

by Pan, Xiaoqing , Liu, Pengyuan , Mattson, David L , Cowley, Allen W , Roberts, Michelle L , Li, Yingchuan , Kotchen, Theodore A , Liu, Yong , Kidambi, Srividya , Liang, Mingyu

2018

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Journal Article

Stability of global methylation profiles of whole blood and extracted DNA under different storage durations and conditions

Pan, Xiaoqing,

Liu, Pengyuan,

Mattson, David L,

Cowley, Allen W,

Roberts, Michelle L,

Li, Yingchuan,

Kotchen, Theodore A,

Liu, Yong,

Kidambi, Srividya,

Liang, Mingyu

2018

Overview

To test whether DNA samples stored for a prolonged period (20 years) under various storage conditions could be used for comparative methylation studies using reduced representation bisulfite sequencing. Five groups of human blood DNA samples (n = 5-6/group) were compared. The groupings were based on the anticoagulant used storage temperature and duration. Methylation profiles of defined genomic regions in the DNA or blood samples archived for 20 years were similar across all storage temperatures, including 4°C. The level of intersample similarity in archived samples was not significantly different than that in recently collected samples. Archived samples, including DNA stored at 4°C for 20 years, are suitable for comparative studies of DNA methylation.

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Publisher

Future Medicine Ltd

Subject

/ Blood

/ Comparative studies

/ Deoxyribonucleic acid