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Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis
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Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis
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Journal Article
Liposome-based immunotherapy against autoimmune diseases: therapeutic effect on multiple sclerosis
2017
Overview
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis.
Phosphatidylserine-rich liposomes were loaded with disease-specific autoantigen. Therapeutic capability of liposomes was assessed
and
.
Liposomes induced a tolerogenic phenotype in dendritic cells, and arrested autoimmunity, thus decreasing the incidence, delaying the onset and reducing the severity of experimental disease, correlating with an increase in a probably regulatory CD25
FoxP3
CD4
T-cell subset.
This is the first work that confirms phosphatidylserine-liposomes as a powerful tool to arrest multiple sclerosis, demonstrating its relevance for clinical application.
Publisher
Future Medicine Ltd
Subject
/ Antigens
/ Autoantigens - administration & dosage
/ Autoantigens - therapeutic use
/ Disease
/ experimental autoimmune encephalomyelitis
/ Female
/ Lipids
/ Multiple Sclerosis - immunology
/ Multiple Sclerosis - therapy
/ Myelin-Oligodendrocyte Glycoprotein - administration & dosage
/ Myelin-Oligodendrocyte Glycoprotein - immunology
/ Myelin-Oligodendrocyte Glycoprotein - therapeutic use
/ Peptides
/ Peptides - administration & dosage
/ Phosphatidylserines - chemistry
/ Proteins
