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Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis

by Babirye, Diana , Sohn, Hojoon , Nabwire, Sarah , Nalugwa, Talemwa , Moore, David A.J , Katamba, Achilles , Reza, Tania F , Thompson, Ryan , Shete, Priya B , Ferguson, Olivia , Nantale, Mariam , Oyuku, Denis , Fielding, Katherine , Tucker, Austin , Dowdy, David W , Ackerman, Sara , Joloba, Moses , Adams, Katherine , Davis, J. Lucian , Turyahabwe, Stavia , Cattamanchi, Adithya , Handley, Margaret A

in Adult / Community Health Centers - organization & administration / Diagnosis / Female / Global Health / Health facilities / HIV / HIV Infections - complications / HIV Infections - diagnosis / Human immunodeficiency virus / Humans / Infectious Disease / Intervention / Male / Medical diagnosis / Medical laboratories / Microscopy / Middle Aged / Models, Statistical / Molecular biology / Molecular Diagnostic Techniques / Nucleic Acid Amplification Techniques / Onsite / Patients / Point-of-Care Testing / Sputum / Statistical analysis / Time-to-Treatment / Tuberculosis / Tuberculosis - complications / Tuberculosis - diagnosis / Tuberculosis - drug therapy / Uganda

2021

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2021

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2021

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Journal Article

Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis

Babirye, Diana,

Sohn, Hojoon,

Nabwire, Sarah,

Nalugwa, Talemwa,

Moore, David A.J,

Katamba, Achilles,

Reza, Tania F,

Thompson, Ryan,

Shete, Priya B,

Ferguson, Olivia,

Nantale, Mariam,

Oyuku, Denis,

Fielding, Katherine,

Tucker, Austin,

Dowdy, David W,

Ackerman, Sara,

Joloba, Moses,

Adams, Katherine,

Davis, J. Lucian,

Turyahabwe, Stavia,

Cattamanchi, Adithya,

Handley, Margaret A

2021

Overview

A cluster-randomized trial in 20 Ugandan health centers compared a multicomponent strategy (on-site molecular testing for TB, restructuring of clinic workflows, and feedback of quality metrics) with routine care (on-site sputum-smear microscopy and referral-based molecular testing). The intervention led to greater numbers of patients being tested for, receiving a diagnosis of, and being treated for confirmed TB.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Community Health Centers - organization & administration

/ Diagnosis

/ Female

/ Global Health

/ Health facilities

/ HIV