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Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

by Polsky, Sarit , Maahs, David M , Senior, Peter , Afkarian, Maryam , Weinstock, Ruth S , Robiner, William N , Haw, J. Sonya , Perkins, Bruce A , de Boer, Ian H , Molitch, Mark E , Elliott, Thomas G , Karger, Amy B , Pop-Busui, Rodica , Mauer, Michael , Spino, Cathie , Tuttle, Katherine R , Rossing, Peter , Cherney, David Z , Aronson, Ronnie , Wu, Chunyi , Lingvay, Ildiko , Goldfine, Allison B , Pragnell, Marlon , Crandall, Jill P , Umpierrez, Guillermo E , Hirsch, Irl B , Caramori, M. Luiza , Doria, Alessandro , Wallia, Amisha , McGill, Janet B , Galecki, Andrzej T , Parsa, Afshin , Sigal, Ronald J , Rosas, Sylvia E

in Adult / Aged / Albumin / Allopurinol / Allopurinol - adverse effects / Allopurinol - therapeutic use / Blood pressure / Creatinine / Diabetes / Diabetes mellitus (insulin dependent) / Diabetes Mellitus, Type 1 - blood / Diabetes Mellitus, Type 1 - drug therapy / Diabetes Mellitus, Type 1 - physiopathology / Diabetic Nephropathies - prevention & control / Double-Blind Method / Drug dosages / Enzyme Inhibitors - adverse effects / Enzyme Inhibitors - therapeutic use / Excretion / Female / Glomerular filtration rate / Glomerular Filtration Rate - drug effects / Hemoglobin / Humans / International organizations / Intervention / Kidney diseases / Male / Middle Aged / Renin-Angiotensin System / Statistical methods / Treatment Failure / Uric acid / Uric Acid - blood / Xanthine Oxidase - antagonists & inhibitors

2020

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Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

2020

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Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

2020

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Journal Article

Serum Urate Lowering with Allopurinol and Kidney Function in Type 1 Diabetes

Polsky, Sarit,

Maahs, David M,

Senior, Peter,

Afkarian, Maryam,

Weinstock, Ruth S,

Robiner, William N,

Haw, J. Sonya,

Perkins, Bruce A,

de Boer, Ian H,

Molitch, Mark E,

Elliott, Thomas G,

Karger, Amy B,

Pop-Busui, Rodica,

Mauer, Michael,

Spino, Cathie,

Tuttle, Katherine R,

Rossing, Peter,

Cherney, David Z,

Aronson, Ronnie,

Wu, Chunyi,

Lingvay, Ildiko,

Goldfine, Allison B,

Pragnell, Marlon,

Crandall, Jill P,

Umpierrez, Guillermo E,

Hirsch, Irl B,

Caramori, M. Luiza,

Doria, Alessandro,

Wallia, Amisha,

McGill, Janet B,

Galecki, Andrzej T,

Parsa, Afshin,

Sigal, Ronald J,

Rosas, Sylvia E

2020

Overview

In a double-blind trial, patients with type 1 diabetes and early-to-moderate diabetic kidney disease were randomly assigned to receive allopurinol, which may slow the decline in the glomerular filtration rate, or placebo. There were no clinically meaningful benefits of serum urate reduction on kidney outcomes with allopurinol therapy.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Aged

/ Albumin

/ Allopurinol

/ Allopurinol - adverse effects

/ Allopurinol - therapeutic use

/ Blood pressure