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Subanesthetic Ketamine Suppresses Locus Coeruleus–Mediated Alertness Effects: A 7T fMRI Study
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Subanesthetic Ketamine Suppresses Locus Coeruleus–Mediated Alertness Effects: A 7T fMRI Study
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Subanesthetic Ketamine Suppresses Locus Coeruleus–Mediated Alertness Effects: A 7T fMRI Study
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Journal Article
Subanesthetic Ketamine Suppresses Locus Coeruleus–Mediated Alertness Effects: A 7T fMRI Study
2024
Overview
Abstract
Background
The NMDA antagonist S-ketamine is gaining increasing use as a rapid-acting antidepressant, although its exact mechanisms of action are still unknown. In this study, we investigated ketamine in respect to its properties toward central noradrenergic mechanisms and how they influence alertness behavior.
Methods
We investigated the influence of S-ketamine on the locus coeruleus (LC) brain network in a placebo-controlled, cross-over, 7T functional, pharmacological MRI study in 35 healthy male participants (25.1 ± 4.2 years) in conjunction with the attention network task to measure LC-related alertness behavioral changes.
Results
We could show that acute disruption of the LC alertness network to the thalamus by ketamine is related to a behavioral alertness reduction.
Conclusion
The results shed new light on the neural correlates of ketamine beyond the glutamatergic system and underpin a new concept of how it may unfold its antidepressant effects.
Publisher
Oxford University Press
Subject
/ Antidepressive Agents - administration & dosage
/ Antidepressive Agents - pharmacology
/ Behavior
/ Excitatory Amino Acid Antagonists - administration & dosage
/ Excitatory Amino Acid Antagonists - pharmacology
/ Humans
/ Ketamine
/ Ketamine - administration & dosage
/ Locus Coeruleus - diagnostic imaging
/ Locus Coeruleus - drug effects
/ Locus Coeruleus - physiology
/ Male
/ Regular
