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Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
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Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
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Journal Article
Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease
2021
Overview
In this trial, patients with stage 4 chronic kidney disease and poorly controlled hypertension, as confirmed by 24-hour ambulatory blood-pressure monitoring, were randomly assigned to receive chlorthalidone (12.5 mg per day, with increases every 4 weeks if needed to a maximum dose of 50 mg per day) or placebo. Chlorthalidone therapy improved blood-pressure control at 12 weeks as compared with placebo.
Publisher
Massachusetts Medical Society
Subject
/ Albumin
/ Blood Pressure - drug effects
/ Chlorthalidone - administration & dosage
/ Chlorthalidone - adverse effects
/ Chlorthalidone - therapeutic use
/ Diabetes
/ Diuretics - administration & dosage
/ Enzymes
/ Female
/ Glomerular Filtration Rate - drug effects
/ Humans
/ Hypertension - complications
/ Male
/ Natriuretic Peptide, Brain - blood
/ Patients
/ Placebos
/ R&D
/ Renal Insufficiency, Chronic - complications
/ Renin
/ Sodium Chloride Symporter Inhibitors - therapeutic use
/ Veterans
