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Dihydroartemisinin–Piperaquine for the Prevention of Malaria in Pregnancy
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Journal Article
Dihydroartemisinin–Piperaquine for the Prevention of Malaria in Pregnancy
2016
Overview
Malaria causes complications during pregnancy, and its prevention is more challenging in the setting of drug-resistant parasites. This trial from Uganda, where resistance to the standard therapy is common, compares three different drug regimens for prevention of malaria.
In 2007, more than 30 million pregnancies were estimated to have occurred in areas of sub-Saharan Africa in which
Plasmodium falciparum
is endemic.
1
Malaria during pregnancy is associated with placental malaria, adverse birth outcomes, and complications and death in both the mother and the infant.
2
,
3
In sub-Saharan Africa, malaria during pregnancy is estimated to be the cause of low birth weight in up to 20% of deliveries, leading to more than 100,000 infant deaths annually.
2
,
3
Given the high burden of malaria in this vulnerable population, the World Health Organization (WHO) recommends the routine implementation of malaria-preventive measures among . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ Antimalarials - adverse effects
/ Antimalarials - therapeutic use
/ Artemisinins - administration & dosage
/ Artemisinins - adverse effects
/ Drug Administration Schedule
/ Female
/ HIV
/ Human immunodeficiency virus
/ Humans
/ Malaria
/ Malaria - prevention & control
/ Placenta
/ Pregnancy Complications, Parasitic - prevention & control
/ Pyrimethamine - adverse effects
/ Pyrimethamine - therapeutic use
/ Quinolines - administration & dosage
/ Quinolines - adverse effects
/ Sulfadoxine - adverse effects
/ Sulfadoxine - therapeutic use
/ Uganda
/ Vomiting
