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Bacterial Factors That Predict Relapse after Tuberculosis Therapy

by Mac Kenzie, William R , Diem, Lois , Johnson, John L , Chakravorty, Soumitesh , Gupta, Aditi , Dietze, Reynaldo , Colangeli, Roberto , Okwera, Alphonse , Jedrey, Hannah , Chippada Venkata, Uma D , Connell, Roy , Boom, W. Henry , Alland, David , Sherman, David R , Sizemore, Erin E , Kim, Soyeon , Ma, Shuyi

in Adult / Allergies / Antitubercular Agents - pharmacology / Antitubercular Agents - therapeutic use / Area Under Curve / Breakpoints / Clinical trials / Consortia / Data processing / Disease control / Drug resistance / Drug Resistance, Bacterial / Female / Humans / Infectious diseases / Isoniazid / Isoniazid - pharmacology / Isoniazid - therapeutic use / Male / Microbial Sensitivity Tests / Minimum inhibitory concentration / Mycobacterium tuberculosis - drug effects / Mycobacterium tuberculosis - isolation & purification / Patients / Recurrence / Rifampin / Rifampin - pharmacology / Rifampin - therapeutic use / ROC Curve / Treatment Failure / Tuberculosis / Tuberculosis - drug therapy / Tuberculosis - microbiology

2018

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2018

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2018

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Journal Article

Bacterial Factors That Predict Relapse after Tuberculosis Therapy

Mac Kenzie, William R,

Diem, Lois,

Johnson, John L,

Chakravorty, Soumitesh,

Gupta, Aditi,

Dietze, Reynaldo,

Colangeli, Roberto,

Okwera, Alphonse,

Jedrey, Hannah,

Chippada Venkata, Uma D,

Connell, Roy,

Boom, W. Henry,

Alland, David,

Sherman, David R,

Sizemore, Erin E,

Kim, Soyeon,

Ma, Shuyi

2018

Overview

In pretreatment isolates of M. tuberculosis with decrements of the minimum inhibitory concentration of isoniazid or rifampin below the standard resistance breakpoint, higher MIC values were associated with a greater risk of relapse than lower MIC values.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Allergies

/ Antitubercular Agents - pharmacology

/ Antitubercular Agents - therapeutic use

/ Area Under Curve

/ Breakpoints

/ Clinical trials