Asset Details
Do you wish to reserve the book?
When the Mind Cannot Shift: Cognitive Flexibility Impairments in Methamphetamine-Dependent Individuals
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
When the Mind Cannot Shift: Cognitive Flexibility Impairments in Methamphetamine-Dependent Individuals
Do you wish to request the book?
When the Mind Cannot Shift: Cognitive Flexibility Impairments in Methamphetamine-Dependent Individuals
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
When the Mind Cannot Shift: Cognitive Flexibility Impairments in Methamphetamine-Dependent Individuals
2025
Overview
Cognitive flexibility—the ability to adapt cognitive strategies and behavioral responses in changing environments—is a key component of executive function, supporting rule updating and conflict resolution. Individuals with substance addiction often exhibit behavioral rigidity and reduced adaptability, reflecting impairments in this domain. This study examined cognitive flexibility in individuals with methamphetamine dependence through three behavioral tasks—intra-dimensional task switching, extra-dimensional task switching, and the Wisconsin Card Sorting Test (WCST)—in combination with a subjective self-report measure. Results showed that, compared to healthy controls, methamphetamine-dependent individuals demonstrated elevated reaction time switch costs in Intra-dimensional Task Switching and increased accuracy switch costs in Extra-dimensional Task Switching, as well as more perseverative and non-perseverative errors in the WCST. These findings suggested not only reduced performances in explicitly cued rule updating and strategic shifting but also deficits in feedback-driven learning and inflexibility in cognitive set shifting on methamphetamine-dependent individuals. Moreover, their self-reported cognitive flexibility scores were aligned with their objective performance, significantly lower than healthy controls. In summary, these findings revealed consistent cognitive flexibility impairments at both behavioral and subjective levels in individuals with methamphetamine dependence, indicating a core executive dysfunction that may undermine adaptive functioning in real-life contexts. The study offers critical insights into the cognitive mechanisms underlying addiction and provides a theoretical foundation for targeted cognitive interventions.
