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The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
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The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
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Journal Article
The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance
2019
Overview
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.
Publisher
MDPI AG,MDPI
Subject
/ Animals
/ Antineoplastic Agents - therapeutic use
/ Cancer
/ Drug Resistance, Neoplasm - genetics
/ Enzymes
/ Extracellular Matrix - drug effects
/ Extracellular Matrix - metabolism
/ Gene Expression Regulation, Neoplastic
/ Humans
/ Neovascularization, Pathologic - drug therapy
/ Neovascularization, Pathologic - enzymology
/ Neovascularization, Pathologic - genetics
/ Neovascularization, Pathologic - pathology
/ Peptides
/ Proteins
/ Proto-Oncogene Proteins c-bcl-2 - genetics
/ Proto-Oncogene Proteins c-bcl-2 - metabolism
/ Review
/ Tumors
