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Whispering-gallery-mode biosensing: label-free detection down to single molecules
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Journal Article
Whispering-gallery-mode biosensing: label-free detection down to single molecules
2008
Overview
Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor, are generally favored for their ability to obtain quantitative data on intermolecular binding. However, before the recent introduction of resonant microcavities that use whispering gallery mode (WGM) recirculation, sensitivity to single binding events had not materialized. Here we describe the enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor, review its current implementations and applications, and discuss its future possibilities.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Biomedical Engineering/Biotechnology
/ Biosensing Techniques - instrumentation
/ Biosensing Techniques - methods
/ Biosensing Techniques - statistics & numerical data
/ Biosensing Techniques - trends
/ Identification and classification
/ Optics
