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Increased secreted PLA2 in epithelial cells promotes the progression of chronic non-atrophic gastritis to chronic atrophic gastritis through the TGF-β signaling
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Increased secreted PLA2 in epithelial cells promotes the progression of chronic non-atrophic gastritis to chronic atrophic gastritis through the TGF-β signaling
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Journal Article
Increased secreted PLA2 in epithelial cells promotes the progression of chronic non-atrophic gastritis to chronic atrophic gastritis through the TGF-β signaling
2026
Overview
The progression of Chronic gastritis seems to follow a pattern from chronic non-atrophic gastritis (CNAG) to chronic atrophic gastritis (CAG) to cancer, so it is particularly important to block key targets in disease progression. A gene that synthesizes secreted phospholipase A2, attracted our attention.
To study whether phospholipase A2 group 10 (PLA2G10) in epithelial cells promote the progression of CNAG to CAG through the transforming growth factor-β (TGF-β) signaling.
We used RNA microarray and single-cell RNA sequencing datasets for bioinformatics analysis. The effects of PLA2G10 were verified by in vivo and in vitro experiments. The in vivo experiments used SD rats to establish a CNAG model for PLA2G10 and TGF-β intervention to observe the effects on gastric mucosal inflammation. In vitro experiments were conducted using human gastric mucosal epithelial cells (GES-1) for similar interventions.
PLA2G10 inhibition led to the downregulation of TGF-β expression and attenuated the inflammatory response of the gastric mucosa. And the blockade of TGF-β signalling delayed the progression of CNAG to CAG, as evidenced by a reduction in inflammatory cell infiltration, a more regular cellular arrangement, and a reduction in collagen deposition.
Our study shows that PLA2G10 plays a key role in the progression of chronic gastritis and highlights the important role played by the TGF-β signalling pathway in this process.
Publisher
Public Library of Science,PLOS,Public Library of Science (PLoS)
Subject
/ Cells
/ Datasets
/ Epithelial Cells - metabolism
/ Epithelial Cells - pathology
/ Gastritis, Atrophic - genetics
/ Gastritis, Atrophic - metabolism
/ Gastritis, Atrophic - pathology
/ Genomics
/ Humans
/ Male
/ Medicine and Health Sciences
/ Ontology
/ Phospholipases A2 - genetics
/ Phospholipases A2 - metabolism
/ Rats
/ Research and analysis methods
/ RNA
/ Transforming Growth Factor beta - metabolism
