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Identification of a common immune regulatory pathway induced by small heat shock proteins, amyloid fibrils, and nicotine
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Identification of a common immune regulatory pathway induced by small heat shock proteins, amyloid fibrils, and nicotine
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Journal Article
Identification of a common immune regulatory pathway induced by small heat shock proteins, amyloid fibrils, and nicotine
2018
Overview
Although certain dogma portrays amyloid fibrils as drivers of neurodegenerative disease and neuroinflammation, we have found, paradoxically, that amyloid fibrils and small heat shock proteins (sHsps) are therapeutic in experimental autoimmune encephalomyelitis (EAE). They reduce clinical paralysis and induce immunosuppressive pathways, diminishing inflammation. A key question was the identification of the target for these molecules. When sHsps and amyloid fibrils were chemically cross-linked to immune cells, a limited number of proteins were precipitated, including the α7 nicotinic acetylcholine receptor (α7 NAChR). The α7 NAChR is noteworthy among the over 20 known receptors for amyloid fibrils, because it plays a central role in a well-defined immune-suppressive pathway. Competitive binding between amyloid fibrils and α-bungarotoxin to peritoneal macrophages (MΦs) confirmed the involvement of α7 NAChR. The mechanism of immune suppression was explored, and, similar to nicotine, amyloid fibrils inhibited LPS induction of a common set of inflammatory cytokines while inducing Stat3 signaling and autophagy. Consistent with this, previous studies have established that nicotine, sHsps, and amyloid fibrils all were effective therapeutics in EAE. Interestingly, B lymphocytes were needed for the therapeutic effect. These results suggest that agonists of α7 NAChR might have therapeutic benefit for a variety of inflammatory diseases.
Publisher
National Academy of Sciences
Subject
Acetylcholine receptors (nicotinic)
/ alpha7 Nicotinic Acetylcholine Receptor - immunology
/ Animals
/ Encephalomyelitis, Autoimmune, Experimental - immunology
/ Encephalomyelitis, Autoimmune, Experimental - pathology
/ Experimental allergic encephalomyelitis
/ Fibrils
/ Heat-Shock Proteins - immunology
/ Humans
/ Macrophages, Peritoneal - immunology
/ Macrophages, Peritoneal - pathology
/ Mice
/ Nicotine
/ Proteins
