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Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host
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Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host
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Journal Article
Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host
2019
Overview
Siderophores, iron-scavenging small molecules, are fundamental to bacterial nutrient metal acquisition and enable pathogens to overcome challenges imposed by nutritional immunity. Multimodal imaging mass spectrometry allows visualization of host−pathogen iron competition, by mapping siderophores within infected tissue. We have observed heterogeneous distributions of Staphylococcus aureus siderophores across infectious foci, challenging the paradigm that the vertebrate host is a uniformly iron-depleted environment to invading microbes.
Publisher
National Academy of Sciences
