Journal Article

Intrauterine growth restriction is associated with persistent aortic wall thickening and glomerular proteinuria during infancy

Zanardo, Vincenzo, Weiner, Gary, Cavallin, Francesco, Fanos, Vassilios, Zaninotto, Martina, Trevisanuto, Daniele, Cosmi, Erich, Visentin, Silvia, Fanelli, Tiziana

2011

Overview

Low birth weight, caused either by preterm birth or by intrauterine growth restriction, has recently been associated with increased rates of adult renal and cardiovascular disease. Since aortic intima–media thickening is a noninvasive marker of preclinical vascular disease, we compared abdominal aortic intima–media thickness among intrauterine growth restricted and equivalent gestational age fetuses in utero and at 18 months of age. The relationship between intrauterine growth restriction, fetal aortic thickening, and glomerular function during infancy was measured by enrolling 44 mothers with single-fetus pregnancies at 32 weeks gestation: 23 growth restricted and 21 of appropriate gestational age as controls. Abdominal aortic intima–media thickness was measured by ultrasound at enrollment and again at 18 months of age. Fetuses with intrauterine growth restriction had significantly higher abdominal aortic intima–media thickness compared with age controls when measured both in utero and at 18 months. At 18 months, the median urinary microalbumin and median albumin–creatinine ratio were significantly higher in those infants who experienced intrauterine growth restriction compared to the controls. Our results show that intrauterine growth restriction is associated with persistent aortic wall thickening and significantly higher microalbuminuria during infancy.

• Publisher: Elsevier Inc,Nature Publishing Group,Elsevier Limited
• Subject: Adult / aIMT / Albuminuria - etiology / Aorta, Abdominal - diagnostic imaging / Aorta, Abdominal - pathology / arterial intima–media wall thickness / Biological and medical sciences / Case-Control Studies / Diseases of mother, fetus and pregnancy / Female / Fetal Growth Retardation - diagnostic imaging / Fetal Growth Retardation - pathology / Fetal Growth Retardation - physiopathology / Gynecology. Andrology. Obstetrics / Humans / Infant / Infant, Newborn / IUGR infants / Kidney Glomerulus - physiopathology / Longitudinal Studies / Male / Medical sciences / Nephrology. Urinary tract diseases / Original / Pregnancy / Pregnancy. Fetus. Placenta / Prospective Studies / Proteinuria - etiology / Tunica Intima - diagnostic imaging / Tunica Intima - pathology / Tunica Media - diagnostic imaging / Tunica Media - pathology / Ultrasonography, Prenatal / Urinary system involvement in other diseases. Miscellaneous / Urinary tract. Prostate gland / urine microalbumin