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Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma
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Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma
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Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma
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Journal Article
Initial experience of correlating parameters of intravoxel incoherent motion and dynamic contrast-enhanced magnetic resonance imaging at 3.0 T in nasopharyngeal carcinoma
2014
Overview
Purpose
To determine the correlation between intravoxel incoherent motion (IVIM) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) parameters.
Methods
Thirty-eight newly diagnosed NPC patients were prospectively enrolled. Diffusion-weighted images (DWI) at 13
b
-values were acquired using a 3.0-T MRI system. IVIM parameters including the pure molecular diffusion (
D
), perfusion-related diffusion (
D*
), perfusion fraction (
f
), DCE-MRI parameters including maximum slope of increase (MSI), enhancement amplitude (EA) and enhancement ratio (
ER
) were calculated by two investigators independently. Intra- and interobserver agreement were evaluated using the intraclass correlation coefficient (
ICC
) and Bland-Altman analysis. Relationships between IVIM and DCE-MRI parameters were evaluated by calculation of Spearman’s correlation coefficient.
Results
Intra- and interobserver reproducibility were excellent to relatively good (ICC
=
0.887-0.997; narrow width of 95 % limits of agreement). The highest correlation was observed between
f
and EA (
r
= 0.633,
P
< 0.001), with a strong correlation between
f
and MSI (
r
= 0.598,
P
= 0.001). No correlation was observed between
f
and ER (
r
= -0.162;
P
= 0.421) or
D*
and DCE parameters (
r
= 0.125–0.307;
P
> 0.119).
Conclusion
This study suggests IVIM perfusion imaging using 3.0-T MRI is feasible in NPC, and
f
correlates significantly with EA and MSI.
Key Points
•
Assessment of tumour perfusion is important in nasopharyngeal carcinoma
.
•
DCE-MRI provided perfusion information with the use of intravenous contrast media
.
•
Perfusion information could be provided by non-invasive IVIM MRI
.
•
IVIM parameter f correlated with DCE-MRI parameters
.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
